Kenny Fiona N, Connelly John T
Centre for Cutaneous Research, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 4 Newark Street, London, E1 2AT, UK.
Cell Tissue Res. 2015 Jun;360(3):571-82. doi: 10.1007/s00441-014-2064-9. Epub 2014 Dec 9.
Integrin receptors mediate the interactions between cells and the extracellular matrix. They not only provide anchorage and a physical linkage to the matrix but also participate in cell signaling and the regulation of diverse cellular functions. In the epidermis of the skin, integrins are essential for tissue structure and integrity, and, under normal homeostatic conditions, the β1 subunit specifically controls the balance between proliferation and terminal differentiation. Integrin expression can also dynamically respond to changes in the cell's environment, and integrin-mediated adhesion is required for keratinocyte migration and re-epithelialization during wound repair. Importantly, integrins participate in keratinocyte mechanotransduction and could potentially regulate cell behavior within the altered mechanical microenvironment of a wound. While the complete functions of integrin receptors in cutaneous wound healing have yet to be determined, recent evidence suggests that cell-matrix interactions are perturbed in chronic and non-healing wounds. Integrins may therefore be a potential therapeutic target for improving wound repair and tissue regeneration.
整合素受体介导细胞与细胞外基质之间的相互作用。它们不仅为细胞提供与基质的锚定和物理连接，还参与细胞信号传导以及多种细胞功能的调节。在皮肤表皮中，整合素对于组织结构和完整性至关重要，并且在正常的稳态条件下，β1亚基专门控制增殖和终末分化之间的平衡。整合素的表达也能动态响应细胞环境的变化，在伤口修复过程中，整合素介导的黏附是角质形成细胞迁移和重新上皮化所必需的。重要的是，整合素参与角质形成细胞的机械转导，并可能在伤口改变的机械微环境中调节细胞行为。虽然整合素受体在皮肤伤口愈合中的完整功能尚未确定，但最近的证据表明，在慢性和不愈合伤口中细胞与基质的相互作用受到干扰。因此，整合素可能是改善伤口修复和组织再生的潜在治疗靶点。
