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[胰腺实性假乳头状瘤的临床特征、手术方式及预后]

[The clinical characteristics surgical procedures and prognosis of solid pseudopapillary tumor of the pancreas].

作者信息

Yang H, Li N, Deng W Y, Luo S X

机构信息

Department of Gastroenterology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450000, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2017 Mar 23;39(3):211-215. doi: 10.3760/cma.j.issn.0253-3766.2017.03.011.

Abstract

To explore the clinical characteristics, surgical procedures and prognosis of solid pseudopapillary tumor of the pancreas(SPTP). The clinical and follow-up data of 55 cases with SPTP in Henan Tumor Hospital from June 2005 to April 2015 were retrospectively analyzed. There were 55 SPTP cases, including 7 males and 48 females. The age ranged from 16 to 76 (median, 33). Clinical presentations of SPTP were not specific. The mean size of the tumor was 7.6 cm (range from 2 to 25cm). Pancreatic head and tail were the most common locations of SPTP. All the patients received surgical resection with a definitive pathological diagnosis. Some immunohistochemical markers were mostly positive, including β-catenin, Vim, Syn, CD10, CD56, PR, etc. With a median follow-up of 53 months, the 1-year, 2-year and 5-year survival rate were 98.1%, 96.1% and 94.0%, respectively. SPTP is an uncommon exocrine pancreatic neoplasm with low malignant potential, which frequently occurs in young women. Preoperative imaging can provide evidence for the selection of treatment modalities among which surgical resection ispreferred. Diagnosis still relies on pathology and immunohistochemistry.

摘要

探讨胰腺实性假乳头状肿瘤(SPTP)的临床特征、手术方式及预后。回顾性分析2005年6月至2015年4月在河南省肿瘤医院收治的55例SPTP患者的临床及随访资料。55例SPTP患者中,男性7例,女性48例。年龄16~76岁(中位年龄33岁)。SPTP的临床表现无特异性。肿瘤平均大小为7.6 cm(范围2~25 cm)。胰头和胰尾是SPTP最常见的部位。所有患者均接受手术切除并获得明确病理诊断。部分免疫组化标志物大多呈阳性,包括β-连环蛋白、波形蛋白、突触素、CD10、CD56、孕激素受体等。中位随访53个月,1年、2年和5年生存率分别为98.1%、96.1%和94.0%。SPTP是一种少见的具有低恶性潜能的胰腺外分泌肿瘤,好发于年轻女性。术前影像学检查可为治疗方式的选择提供依据,首选手术切除。诊断仍依赖病理及免疫组化检查。

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