Moustafa Ahmed A, Kéri Szabolcs, Polner Bertalan, White Corey
a School of Social Sciences and Psychology, Marcs Institute for Brain and Behaviour, Western Sydney University , Penrith , Australia.
b Nyírő Gyula Hospital, National Institute of Psychiatry and Addictions , Budapest , Hungary.
J Neurogenet. 2017 Mar-Jun;31(1-2):17-22. doi: 10.1080/01677063.2017.1301939. Epub 2017 Mar 20.
To understand the cognitive effects of alpha-synuclein polymorphism, we employed a drift diffusion model (DDM) to analyze reward- and punishment-guided probabilistic learning task data of participants with the rare alpha-synuclein gene duplication and age- and education-matched controls. Overall, the DDM analysis showed that, relative to controls, asymptomatic alpha-synuclein gene duplication carriers had significantly increased learning from negative feedback, while they tended to show impaired learning from positive feedback. No significant differences were found in response caution, response bias, or motor/encoding time. We here discuss the implications of these computational findings to the understanding of the neural mechanism of alpha-synuclein gene duplication.
为了解α-突触核蛋白多态性的认知效应，我们采用漂移扩散模型（DDM）来分析携带罕见α-突触核蛋白基因重复的参与者以及年龄和教育程度匹配的对照组在奖励和惩罚引导的概率学习任务数据。总体而言，DDM分析表明，相对于对照组，无症状的α-突触核蛋白基因重复携带者从负面反馈中的学习显著增加，而他们从正面反馈中的学习往往受损。在反应谨慎性、反应偏差或运动/编码时间方面未发现显著差异。我们在此讨论这些计算结果对理解α-突触核蛋白基因重复的神经机制的意义。
