Department of Physiology, University of Szeged, Hungary.
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15992-4. doi: 10.1073/pnas.1006068107. Epub 2010 Aug 23.
alpha-Synuclein (SNCA) plays an important role in the regulation of dopaminergic neurotransmission and neurodegeneration in Parkinson disease. We investigated reward and punishment learning in asymptomatic carriers of a rare SNCA gene duplication who were healthy siblings of patients with Parkinson disease. Results revealed that healthy SNCA duplication carriers displayed impaired reward and intact punishment learning compared with noncarriers. These results demonstrate that a copy number variation of the SNCA gene is associated with selective impairments on reinforcement learning in asymptomatic carriers without the motor symptoms of Parkinson disease.
α-突触核蛋白（SNCA）在调节帕金森病中的多巴胺能神经传递和神经退行性变中起着重要作用。我们研究了无症状的 SNCA 基因重复携带者（帕金森病患者的健康兄弟姐妹）的奖赏和惩罚学习。结果表明，与非携带者相比，健康的 SNCA 重复携带者表现出受损的奖赏和完整的惩罚学习。这些结果表明，SNCA 基因的拷贝数变异与无症状携带者的强化学习选择性损伤有关，而这些携带者没有帕金森病的运动症状。
