Thiwan Syed I M, Drossman Douglas A
Dr. Thiwan serves as a Gastroenterology fellow and Dr. Drossman as Professor of Medicine and Psychiatry in the Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC.
Gastroenterol Hepatol (N Y). 2006 Sep;2(9):678-688.
Functional gastrointestinal disorders (FGIDs) are complex in their physiology and clinical presentation. With no known biologic marker, investigators and clinicians use the Rome criteria to make a positive diagnosis. Psychosocial factors, although not part of these criteria, do contribute to illness presentation, severity, healthcare-seeking behavior and response to treatment. In this regard, psychoactive drugs are valuable in the management of FGIDs, particularly for patients with severe symptoms. The appropriate selection of antidepressants based on predominant symptom, side-effect profile, and psychological condition is an integral part of a successful management program.
功能性胃肠疾病（FGIDs）在生理和临床表现方面都很复杂。由于没有已知的生物学标志物，研究人员和临床医生使用罗马标准来做出肯定诊断。心理社会因素虽然不是这些标准的一部分，但确实会影响疾病的表现、严重程度、就医行为和对治疗的反应。在这方面，精神活性药物在FGIDs的管理中很有价值，特别是对于症状严重的患者。根据主要症状、副作用特征和心理状况适当选择抗抑郁药是成功管理方案的一个组成部分。
