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遗传性心脏病的人群归因危险度。伊朗亚兹德新生儿的危险因素。

Population attributable danger of hereditary heart breaks. Risk factors among newborns in Yazd, Iran.

作者信息

Taheri M, Dehghani A, Noorishadkam M, Tabatabaei S M

机构信息

Faculty of Health, Department of Biostatistics & Epidemiology, Shahid Sadoughi University of Medical Sciences ,Yazd, Iran.

Hospital of Shahid Sadoghi, Department of Neonatal, Research Centre for premature neonate Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

出版信息

J Med Life. 2015;8(Spec Iss 3):212-217.

Abstract

hereditary heart problem are cardiac problems that develop prior to birth and influence the newborns' basic performance of heart. Different kinds of deficiency can range from mild (e.g. a small hole between the heart chambers) to severe (like a flaw or weakness into a heart part). This case-control research performed to evaluate PAR congenital heart defects danger parameters between newborns from 2012 to 2013 in Yazd hospitals. The defects were identified through echocardiography and recorded based on the 10th Revision of Diseases International Classification (DIC10). The total amount of cases were 96, of whom 14 were excluded regarding that the shortage of cooperation or insufficient data. One hundred and sixty five sex and region matched controls selected through random sampling involved in the research. Population Attributable Risk (PAR) utilized to evaluate and measure the priorities of the danger parameters. Finally, the Levin formula utilized to evaluate the regulate community ascribable portion. Regulated odds rates evaluated for the danger parameters. The outcomes revealed that the greatest odds ratio belonged to the maternal history of stillbirth, lack of multivitamin use before pregnancy, maternal obesity, and overweight. The calculation of the adjusted Population Attributable Fraction in risk factors indicated that the highest fraction of the causes of natural heart malformations was associated with overweight and obesity. The current research showed that several factors that can impact the congenital heart defects. It concluded that although overweight and obesity had a weaker association than the other 2 parameters, they have a higher prevalence and a greater attributable risk.

摘要

遗传性心脏问题是指在出生前就出现并影响新生儿心脏基本功能的心脏问题。不同类型的缺陷程度各异,从轻度(例如心脏腔室之间有小孔)到重度(如心脏某部分存在缺陷或薄弱)。本病例对照研究旨在评估2012年至2013年亚兹德医院新生儿先天性心脏缺陷的危险因素参数。通过超声心动图识别缺陷,并根据《国际疾病分类第10版》(DIC10)进行记录。病例总数为96例,其中14例因合作不足或数据不充分而被排除。通过随机抽样选取了165名性别和地区匹配的对照参与研究。采用人群归因风险(PAR)来评估和衡量危险因素的优先级。最后,利用莱文公式评估调整后的社区归因比例。对危险因素的调整后比值比进行了评估。结果显示,最高的比值比与死产的母亲病史、孕前未使用多种维生素、母亲肥胖和超重有关。对危险因素中调整后的人群归因分数的计算表明,先天性心脏畸形病因的最高比例与超重和肥胖有关。当前研究表明,有几个因素会影响先天性心脏缺陷。研究得出结论,尽管超重和肥胖与其他两个参数的关联较弱,但它们的患病率较高且归因风险更大。

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Recurrence of congenital heart defects in families.家族性先天性心脏缺陷的复发
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