Young R H, Clement P B
James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston 02114.
Am J Clin Pathol. 1988 Mar;89(3):308-14. doi: 10.1093/ajcp/89.3.308.
Three adenomyoepitheliomas of the breast that occurred in elderly women are reported and the features of the six previously reported cases are reviewed. The tumors were characterized by a proliferation of glands lined by a dual population of cells. On the basis of their appearance in rountinely stained sections and their immunohistochemical features, the inner cells were interpreted as epithelial, whereas the cells of the outer layer, which typically had abundant, clear cytoplasm, were interpreted as myoepithelial. One tumor was associated with, and may have arisen from, an adenomyoepithelial type of adenosis. Despite relatively bland cytologic features, one lesion recurred three times over the course of seven years. Follow-up for the other two patients is of short duration. Because of the possibility of local recurrence, wide local excision is recommended.
报告了3例发生于老年女性的乳腺腺肌上皮瘤，并对之前报道的6例病例的特征进行了回顾。这些肿瘤的特征是由双细胞群衬覆的腺体增生。根据其在常规染色切片中的表现及其免疫组化特征，内层细胞被解释为上皮细胞，而外层细胞通常具有丰富的透明细胞质，被解释为肌上皮细胞。1例肿瘤与腺肌上皮型腺病相关，可能起源于此。尽管细胞学特征相对温和，但1例病变在7年中复发了3次。另外2例患者的随访时间较短。由于存在局部复发的可能性，建议行广泛局部切除。
