Ruffolo E F, Maluf H M, Koerner F C
James Homer Wright Laboratory of Pathology, Massachusetts General Hospital, Boston 02114, USA.
Virchows Arch. 1996 Aug;428(6):319-24. doi: 10.1007/BF00202198.
We report the pathological characteristics of a variant of mammary endocrine tumour, predominantly formed from cytologically bland spindle cells. This neoplasm grows as a red, well defined mass lacking the usual macroscopical characteristics of breast cancer. Within smoothly contoured aggregates arranged in an insular pattern, delicate capillaries and collagen bundles support the neoplastic epithelial cells. Most of the tumour cells possess a slender spindle shape and form a solid or fenestrated sheet, but a few appear cuboidal and create glands. Immunohistochemical studies demonstrate that the spindle cells and the glandular cells constitute a single population. Both types of cells stain for neuroendocrine markers (chromogranin, synaptophysin, and CD 57), carcinoembryonic antigen, keratin 8/18, S-100 protein, and receptors for oestrogen and progesterone. Many of the tumour cells possess argyrophilic granules, and electron microscopy may reveal dense core granules.
我们报告了一种乳腺内分泌肿瘤变体的病理特征，该肿瘤主要由细胞形态温和的梭形细胞构成。此肿瘤呈红色、边界清晰的肿块生长，缺乏乳腺癌常见的宏观特征。在呈岛状排列的轮廓光滑的细胞聚集体内，纤细的毛细血管和胶原束支撑着肿瘤上皮细胞。大多数肿瘤细胞呈细长梭形，形成实性或有窗孔的片状结构，但少数细胞呈立方形并形成腺体。免疫组织化学研究表明，梭形细胞和腺细胞构成单一细胞群体。两种类型的细胞均对神经内分泌标志物（嗜铬粒蛋白、突触素和CD 57）、癌胚抗原、角蛋白8/18、S-100蛋白以及雌激素和孕激素受体呈阳性染色。许多肿瘤细胞含有嗜银颗粒，电子显微镜检查可能显示致密核心颗粒。
