SF-吡啶基芳基-λ-碘鎓盐及其作为亲电试剂在合成后期制备SF-吡啶衍生物中的应用。
SF-Pyridylaryl-λ-iodonium salts and their utility as electrophilic reagents to access SF-pyridine derivatives in the late-stage of synthesis.
作者信息
Das Prajwalita, Takada Masahiro, Matsuzaki Kohei, Saito Norimichi, Shibata Norio
机构信息
Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
Pharmaceutical Division, Ube Industries, Ltd, Seavans North Bldg., 1-2-1 Shibaura, Minato-ku, Tokyo 105-8449, Japan.
出版信息
Chem Commun (Camb). 2017 Mar 30;53(27):3850-3853. doi: 10.1039/c7cc01043e.
Electrophilic pentafluorosulfanyl (SF) heteroarylation of target molecules using novel reagents is described. Unsymmetrical diaryliodonium reagents 1 having 2-SF-pyridine have been synthesized in good yields. They are efficient electrophilic reagents for carbon and heterocentered nucleophiles, producing the corresponding SF-pyridine derivatives in good to excellent yields.
描述了使用新型试剂对目标分子进行亲电五氟硫烷基（SF）杂芳基化反应。已高收率合成了具有2-SF-吡啶的不对称二芳基碘鎓试剂1。它们是用于碳亲核试剂和杂中心亲核试剂的高效亲电试剂，能以良好至优异的收率生成相应的SF-吡啶衍生物。
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