甲基乙烯基酮对对醌甲基化物的对映选择性劳乌特－库里尔型1,6-共轭加成反应
Enantioselective Rauhut-Currier-Type 1,6-Conjugate Addition of Methyl Vinyl Ketone to para-Quinone Methides.
作者信息
Kang Tian-Chen, Wu Lu-Ping, Yu Qi-Wen, Wu Xin-Yan
机构信息
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
出版信息
Chemistry. 2017 May 11;23(27):6509-6513. doi: 10.1002/chem.201700520. Epub 2017 Apr 19.
PMID:28317199
Abstract
An unprecedented Rauhut-Currier-type 1,6-conjugate addition has been developed. With chiral cyclohexane-based phosphine-amide catalyst 3 h, the 1,6-conjugate reaction has been achieved to produce chiral diarylmethine compounds in excellent yields (91-99 %) and enantioselectivities (92-98 % ee).
摘要
一种前所未有的Rauhut-Currier型1,6-共轭加成反应已被开发出来。使用基于手性环己烷的膦酰胺催化剂3 h，实现了1,6-共轭反应，以优异的产率（91-99 %）和对映选择性（92-98 % ee）生成手性二芳基甲烷化合物。
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