手性膦硫脲催化的对映选择性分子内 Rauhut-Currier 反应。
Enantioselective intramolecular Rauhut-Currier reaction catalyzed by chiral phosphinothiourea.
机构信息
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, 200237, P. R. China.
出版信息
Chem Commun (Camb). 2011 Feb 7;47(5):1491-3. doi: 10.1039/c0cc04412a. Epub 2010 Dec 15.
PMID:21161087
Abstract
Chiral organophosphine-catalyzed enantioselective Rauhut-Currier reaction has been disclosed for the first time. With L-valine-derived phosphinothiourea, the intramolecular Rauhut-Currier reaction of bis(enones) was achieved in good yields (up to 99%) with excellent enantioselectivities (up to 99.4% ee).
摘要
手性膦催化的对映选择性 Rauhut-Currier 反应首次被揭示。采用 L-缬氨酸衍生的磷酰基硫脲，双烯酮的分子内 Rauhut-Currier 反应以优异的对映选择性（高达 99.4%ee）获得了良好的收率（高达 99%）。
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