Buckley N M, Diamant S, Frasier I D, Owusu K
Department of Physiology and Biophysics, Albert Einstein College of Medicine, New York, New York 10461.
Am J Physiol. 1988 Feb;254(2 Pt 1):G156-61. doi: 10.1152/ajpgi.1988.254.2.G156.
The possible role of histamine or adenosine in intestinal blood flow autoregulation in 1-mo-old swine was examined by obtaining pressure-flow relationships before and during intestinal histamine H1- or adenosine-receptor blockade in two groups of fasting animals under anesthesia with pentobarbital sodium (30 mg/kg). Changes in abdominal and thoracic aortic pressures and in superior mesenteric and left renal arterial flows were recorded during controlled aortic compression above the celiac artery. After control intestinal and renal pressure-flow relationships were obtained, a test dose of agonist (0.1 microgram histamine or 0.2 microgram adenosine/kg body wt) was given into the superior mesenteric artery. Then an intra-arterial infusion of blocking agent was started (0.1 mg.kg-1.min-1 chlorpheniramine or 10 mumol/min theophylline). Degree of blockade was assessed with doses of agonist given before and after a second set of intestinal and renal pressure-flow relationships was obtained. Complete blockade of intestinal vascular histamine H1-receptors with chlorpheniramine abolished, and incomplete blockade of adenosine-receptors with theophylline attenuated, intestinal blood flow autoregulation. Renal blood flow autoregulation remained at its control level. These results indicate that both histamine and adenosine are among the physiological vasodilators contributing to intestinal blood flow autoregulation when arterial pressure is decreased in young swine.
通过在两组戊巴比妥钠（30mg/kg）麻醉下的禁食动物中，在肠道组胺H1或腺苷受体阻断之前和期间获取压力-流量关系，研究了组胺或腺苷在1月龄猪肠道血流自动调节中的可能作用。在腹腔动脉上方进行控制性主动脉压迫期间，记录腹主动脉和胸主动脉压力以及肠系膜上动脉和左肾动脉血流的变化。在获得对照肠道和肾脏压力-流量关系后，将测试剂量的激动剂（0.1微克组胺或0.2微克腺苷/千克体重）注入肠系膜上动脉。然后开始动脉内输注阻断剂（0.1mg·kg-1·min-1氯苯那敏或10μmol/min茶碱）。在获得第二组肠道和肾脏压力-流量关系之前和之后给予激动剂剂量，评估阻断程度。氯苯那敏对肠道血管组胺H1受体的完全阻断消除了肠道血流自动调节，茶碱对腺苷受体的不完全阻断减弱了肠道血流自动调节。肾血流自动调节保持在对照水平。这些结果表明，当幼猪动脉压降低时，组胺和腺苷都是有助于肠道血流自动调节的生理性血管舒张剂。
