Buckley N M, Diamant S, Frasier I D, Owusu K
Department of Physiology and Biophysics, Albert Einstein College of Medicine, New York, N.Y.
Biol Neonate. 1988;54(1):49-59. doi: 10.1159/000242823.
Vascular resistance changes to single intra-arterial injections of norepinephrine, histamine and adenosine were examined in 12 kidney and 10 jejunum preparations perfused in situ in fasting swine anesthetized with pentobarbital. Threshold doses were higher and other response magnitudes were smaller in the nonautoregulating renal circulation of 1-week-olds and jejunal circulation of 2-week-olds than in autoregulating circulations of 1-month-olds. These results suggest a correlation between maturation of autoregulatory capability and of vasodilator histamine and adenosine receptors.
在用戊巴比妥麻醉的禁食猪体内，对12个原位灌注的肾脏标本和10个空肠标本进行了研究，观察了动脉内单次注射去甲肾上腺素、组胺和腺苷后血管阻力的变化。与1月龄猪的具有自身调节功能的循环系统相比，1周龄猪的无自身调节功能的肾循环系统以及2周龄猪的空肠循环系统，其阈剂量更高，其他反应幅度更小。这些结果表明，自身调节能力的成熟与血管舒张性组胺和腺苷受体的成熟之间存在相关性。
