[双膦酸盐相关颌骨坏死的临床分析]
[Clinical analysis of bisphosphonate-related osteonecrosis of the jaw].
作者信息
Jiaxing Gong, Huiming Wang
机构信息
Dept. of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Medical School, Zhejiang University, Hangzhou 310003, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Aug 1;34(4):358-363. doi: 10.7518/hxkq.2016.04.008.
OBJECTIVE
The study aims to analyze patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ).
METHODS
Twelve patients treated in the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Me-dical School, Zhejiang University from May 2013 to September 2015 were included. Patients' basic situation, medication, clinical symptoms, therapies, and effects were obtained and analyzed.
RESULTS
The treatment of nine patients focused on the mandible, whereas that of three patients was on the maxilla. The clinical symptoms appeared from 10 to 80 months, with an average of about (28.00±21.42) months. Nine patients had tooth extraction history. After operation (nine patients), eight were treated, one had stable in bone exposure and three patients received conservative treatment.
CONCLUSIONS
Intravenous infusion of bisphosphonates can induce BRONJ. The mandible is commonly involved and tooth extraction is a big inducement. Treatments nowadays seek to relieve clinical symptoms, but prevention is more important.
目的
本研究旨在分析双膦酸盐相关颌骨坏死（BRONJ）患者。
方法
纳入2013年5月至2015年9月在浙江大学医学院附属第一医院口腔颌面外科接受治疗的12例患者。获取并分析患者的基本情况、用药情况、临床症状、治疗方法及效果。
结果
9例患者的治疗集中在下颌骨，3例患者的治疗集中在上颌骨。临床症状出现时间为10至80个月，平均约（28.00±21.42）个月。9例患者有拔牙史。术后（9例患者），8例接受治疗，1例骨暴露稳定，3例患者接受保守治疗。
结论
静脉输注双膦酸盐可诱发BRONJ。下颌骨常受累，拔牙是一个重要诱因。目前的治疗旨在缓解临床症状，但预防更为重要。
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