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What's the Buzz About Hydroxynorketamine? Is It the History, the Story, the Debate, or the Promise?

作者信息

Abdallah Chadi G

机构信息

Clinical Neurosciences Division, National Center for PTSD, US Department of Veterans Affairs, West Haven; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

出版信息

Biol Psychiatry. 2017 Apr 15;81(8):e61-e63. doi: 10.1016/j.biopsych.2017.01.002.

DOI:10.1016/j.biopsych.2017.01.002
PMID:28317551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5484143/
Abstract
摘要

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Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications.羟基去甲卡西酮：药理学与潜在治疗应用。
Pharmacol Rev. 2021 Apr;73(2):763-791. doi: 10.1124/pharmrev.120.000149.
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Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine.重现精神分裂症的多巴胺病理生理学及其改善方法：氯胺酮的转化成像研究。
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()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions.()-羟基去甲氯胺通过 mGlu 受体发挥抗抑郁作用。
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6441-6450. doi: 10.1073/pnas.1819540116. Epub 2019 Mar 13.
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Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action.羟基去甲氯胺酮：对氯胺酮抗抑郁作用的N-甲基-D-天冬氨酸受体假说的启示
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No Sex-Specific Differences in the Acute Antidepressant Actions of (R)-Ketamine in an Inflammation Model.（R）-氯胺酮在炎症模型中无急性抗抑郁作用的性别差异。
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Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression.氯胺酮及其代谢产物作为新型雌激素受体配体：诱导细胞色素 P450 和 AMPA 谷氨酸受体基因表达。
Biochem Pharmacol. 2018 Jun;152:279-292. doi: 10.1016/j.bcp.2018.03.032. Epub 2018 Apr 3.

本文引用的文献

1
Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.回复：氯胺酮与羟基去甲氯胺酮的抗抑郁作用
Biol Psychiatry. 2017 Apr 15;81(8):e69-e71. doi: 10.1016/j.biopsych.2016.08.039. Epub 2016 Sep 30.
2
Antidepressant Actions of Ketamine Versus Hydroxynorketamine.氯胺酮与羟基去甲氯胺酮的抗抑郁作用
Biol Psychiatry. 2017 Apr 15;81(8):e65-e67. doi: 10.1016/j.biopsych.2016.06.029. Epub 2016 Sep 28.
3
NMDAR inhibition-independent antidepressant actions of ketamine metabolites.氯胺酮代谢物的非NMDAR抑制依赖性抗抑郁作用。
Nature. 2016 May 26;533(7604):481-6. doi: 10.1038/nature17998. Epub 2016 May 4.
4
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS.氯胺酮的作用机制：通往速效抗抑郁药之路。
Depress Anxiety. 2016 Aug;33(8):689-97. doi: 10.1002/da.22501. Epub 2016 Apr 6.
5
Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression.氯胺酮的血浆代谢物与重性抑郁反应、诊断和副作用的关系。
Biol Psychiatry. 2012 Aug 15;72(4):331-8. doi: 10.1016/j.biopsych.2012.03.004. Epub 2012 Apr 18.
6
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.静息状态下 NMDA 受体阻断可迅速引发抗抑郁行为反应。
Nature. 2011 Jun 15;475(7354):91-5. doi: 10.1038/nature10130.
7
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.mTOR 依赖性突触形成是 NMDA 拮抗剂快速抗抑郁作用的基础。
Science. 2010 Aug 20;329(5994):959-64. doi: 10.1126/science.1190287.
8
Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors.氯胺酮抗抑郁作用的细胞机制：α-氨基-3-羟基-5-甲基异恶唑-4-丙酸受体的作用
Biol Psychiatry. 2008 Feb 15;63(4):349-52. doi: 10.1016/j.biopsych.2007.05.028. Epub 2007 Jul 23.
9
Antidepressant effects of ketamine in depressed patients.氯胺酮对抑郁症患者的抗抑郁作用。
Biol Psychiatry. 2000 Feb 15;47(4):351-4. doi: 10.1016/s0006-3223(99)00230-9.
10
Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.抗抑郁治疗后N-甲基-D-天冬氨酸（NMDA）受体的适应性：对抑郁症药物治疗的启示。
Pharmacopsychiatry. 1996 Jan;29(1):23-6. doi: 10.1055/s-2007-979537.