Ullah Sami, Hussain Shah, Khan Sadiq Noor, Khurram Mohammad, Khan Iqbal, Khan Murad Ali
Department of Chemistry, Kohat University of Science and Technology, Kohat, KPK, Pakistan.
Department of Medical Lab Technology, University of Haripur, Haripur, Pakistan.
Int J Mycobacteriol. 2017 Jan-Mar;6(1):102-105. doi: 10.4103/ijmy.ijmy_11_17.
Tuberculosis (TB) ranks as the second leading cause of deaths due to infectious diseases. Although global efforts have been made to control TB, still, this is a serious threat as Mycobacterium tuberculosis (MTB) produced resistance against both the first- and second-line drugs. The increasing incidence of multidrug-resistant, extremely drug resistant, and totally drug-resistant TB worldwide requires extra efforts to search for new anti-TB drugs.
The present study evaluated the antimycobacterial activities of Citrullus colocynthis, Calotropis procera, Ricinus communis, Capparis decidua, and Fagonia cretica plants' extracts against rifampicin-sensitive (H37Rv) and rifampicin-resistant (TMC331) strains of MTB.
Out of 44 extracts, 19 extracts were found active against H37Rv sensitive strain. Highest activities were observed in chloroform extract of C. colocynthis (leaves) and n-hexane extract of R. communis (seeds) with minimum inhibitory concentration values of 2.5 mg/ml each.
Results show antimycobacterial potential in some of the fractions of studied plants that may be utilized further for isolation of active compounds and as a possible cure against TB.
结核病是因传染病导致死亡的第二大主要原因。尽管全球已努力控制结核病，但由于结核分枝杆菌（MTB）对一线和二线药物均产生耐药性，这仍然是一个严重威胁。全球耐多药、广泛耐药和全耐药结核病发病率不断上升，需要付出额外努力来寻找新的抗结核药物。
本研究评估了苦西瓜、牛角瓜、蓖麻、光叶海桐和刺果甘草植物提取物对结核分枝杆菌的利福平敏感菌株（H37Rv）和利福平耐药菌株（TMC331）的抗分枝杆菌活性。
在44种提取物中，发现19种提取物对H37Rv敏感菌株有活性。在苦西瓜（叶）的氯仿提取物和蓖麻（种子）的正己烷提取物中观察到最高活性，最低抑菌浓度值均为2.5毫克/毫升。
结果表明，所研究植物的某些提取物具有抗分枝杆菌潜力，可进一步用于分离活性化合物，并可能作为治疗结核病的药物。
