Ravi Chitrakar, Adimurthy Subbarayappa
Natural Products & Green Chemistry, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar-364002, Gujarat, India.
Chem Rec. 2017 Oct;17(10):1019-1038. doi: 10.1002/tcr.201600146. Epub 2017 Mar 20.
Imidazo[1,2-a]pyridines play an important role in medicinal chemistry. In spite of very drastic developments on syntheses and functionalization in this area, the use of inexpensive catalysts and mild reaction conditions constitutes an important role in pharmaceutical applications. This account describes our recent efforts on the development of new methods for the synthesis of imidazo[1,2-a]pyridines using readily available starting substrates and catalysts under very mild reaction conditions. In the direction of enhancement of biological activity, we also described the synthesis of functionalized imidazo [1,2-a]pyridine derivatives.
咪唑并[1,2 - a]吡啶在药物化学中起着重要作用。尽管该领域在合成和官能团化方面取得了巨大进展，但使用廉价催化剂和温和反应条件在药物应用中仍起着重要作用。本综述介绍了我们近期在开发新方法方面所做的努力，即在非常温和的反应条件下，使用易得的起始底物和催化剂合成咪唑并[1,2 - a]吡啶。在增强生物活性的方向上，我们还描述了官能团化咪唑并[1,2 - a]吡啶衍生物的合成。
