[变形链球菌致龋毒力转录调节因子的研究进展]
[Development of transcriptional regulators of Streptococcus mutans in cariogenic virulence].
作者信息
Lan Li, Bowen Zhang, Jiyao Li
机构信息
State Key Laboratory of Oral Diseases, Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Oral Diseases, Dept. of Head and Nech Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Dec 1;34(6):643-646. doi: 10.7518/hxkq.2016.06.018.
Abstract
Some transcriptional regulators contribute to the expression of Streptococcus mutans (S. mutans) cariogenic virulence factors. Although the target sequence transcriptional regulators anchored on the cell wall and the molecular mechanism of the regulation of S. mutans are yet to be clarified, certain global regulators potentially associated with the cariogenicity of S. mutans have been identified. This review is about these related transcriptional regulators, their function, and possible mechanisms.
摘要
一些转录调节因子有助于变形链球菌致龋毒力因子的表达。尽管锚定在细胞壁上的靶序列转录调节因子以及变形链球菌的调节分子机制尚待阐明，但已鉴定出某些可能与变形链球菌致龋性相关的全局调节因子。本文综述了这些相关的转录调节因子、它们的功能及可能的机制。
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[Development of transcriptional regulators of Streptococcus mutans in cariogenic virulence].[变形链球菌致龋毒力转录调节因子的研究进展]
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本文引用的文献
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BrpA is involved in regulation of cell envelope stress responses in Streptococcus mutans.BrpA 参与调控变形链球菌细胞包膜应激反应。
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A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator.一种新型双色氨酸肽信息素通过 Rgg 调控因子控制链球菌属的感受态。
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Microbiology of dental plaque biofilms and their role in oral health and caries.牙菌斑生物膜的微生物学及其在口腔健康和龋齿中的作用。
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Characterization of mleR, a positive regulator of malolactic fermentation and part of the acid tolerance response in Streptococcus mutans.鉴定 mleR，其为变链菌中苹果酸-乳酸发酵的正调控因子和耐酸应答的一部分。
BMC Microbiol. 2010 Feb 23;10:58. doi: 10.1186/1471-2180-10-58.
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Role of GlnR in acid-mediated repression of genes encoding proteins involved in glutamine and glutamate metabolism in Streptococcus mutans.GlnR 在参与谷氨酸盐和谷氨酸代谢的蛋白编码基因的酸介导抑制中的作用在变异链球菌中。
Appl Environ Microbiol. 2010 Apr;76(8):2478-86. doi: 10.1128/AEM.02622-09. Epub 2010 Feb 19.
6
The hdrRM operon of Streptococcus mutans encodes a novel regulatory system for coordinated competence development and bacteriocin production.变形链球菌 hdrRM 操纵子编码了一种新型调控系统，用于协调感受态发育和细菌素产生。
J Bacteriol. 2010 Apr;192(7):1844-52. doi: 10.1128/JB.01667-09. Epub 2010 Jan 29.
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