Zito Marino Federica, Ascierto Paolo Antonio, Rossi Giulio, Staibano Stefania, Montella Marco, Russo Daniela, Alfano Roberto, Morabito Alessandro, Botti Gerardo, Franco Renato
a Pathology Unit , Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS , Naples , Italy.
b Pathology Unit , Università della campania 'Luigi Vanvitelli' , Naples , Italy.
Expert Opin Biol Ther. 2017 Jun;17(6):735-746. doi: 10.1080/14712598.2017.1309387. Epub 2017 Mar 28.
Tumor-infiltrating lymphocytes (TILs) are frequently observed in several tumors, reflecting the dynamic process of '"cancer immunoediting"'. Prognostic and predictive values of TILs have been demonstrated in different cancers, proving their pivotal role in clinical outcome. In recent years, new therapies targeting immune checkpoint inhibitors, especially CTLA-4 and PD-1/PDL-1 pathways, have been introduced into clinical practice. In this context, TILs may even have a possible utility as a predictive biomarker for immunotherapy response. Areas covered: In this review, the authors summarize the most relevant knowledge related to TILs. This includes their prognostic and predictive significance in various types of tumour and the recent findings about their potential role in the cancer immunotherapy. Expert opinion: TILs evaluation could lead to a predictive biomarker for immunotherapy effectiveness in several cancer types. Furthermore, typing of TILs subpopulation could have clinical relevance in patient selection for treatment with immune checkpoint inhibitors. However further studies are still needed.
肿瘤浸润淋巴细胞（TILs）在多种肿瘤中经常可见，反映了“癌症免疫编辑”的动态过程。TILs的预后和预测价值已在不同癌症中得到证实，证明了它们在临床结局中的关键作用。近年来，针对免疫检查点抑制剂，尤其是CTLA-4和PD-1/PDL-1通路的新疗法已被引入临床实践。在此背景下，TILs甚至可能作为免疫治疗反应的预测生物标志物具有潜在用途。涵盖领域：在本综述中，作者总结了与TILs相关的最相关知识。这包括它们在各种类型肿瘤中的预后和预测意义以及关于它们在癌症免疫治疗中潜在作用的最新发现。专家意见：TILs评估可能会为多种癌症类型的免疫治疗有效性带来一种预测生物标志物。此外，TILs亚群的分型在免疫检查点抑制剂治疗的患者选择中可能具有临床相关性。然而，仍需要进一步研究。
