Garutti Mattia, Bruno Rachele, Polesel Jerry, Pizzichetta Maria Antonietta, Puglisi Fabio
CRO Aviano, National Cancer Institute, IRCCS, 33081, Aviano, Italy.
Department of Medicine, University of Udine, 33100, Udine, Italy.
Heliyon. 2024 Jun 6;10(12):e32433. doi: 10.1016/j.heliyon.2024.e32433. eCollection 2024 Jun 30.
Numerous studies underscore the relevance of tumor-infiltrating-lymphocytes (TILs) as important prognostic factors for melanoma. This meta-analysis aims to provide a comprehensive literature overview elucidating their role in predicting patient outcomes, specifically investigating the association between TIL density and prognosis.
From an initial pool of 6094 records, 16 met the eligibility criteria, encompassing a collective cohort of 16021 patients. Data on TIL counts, clinical characteristics, and survival metrics (5-year overall survival [5yOS], 10-year overall survival [10yOS], and 5-year melanoma-specific survival [5yMSS]) were extracted from each study and expressed as proportions. Results were graphically presented using forest plots, reporting the estimates from individual studies, summary estimates, and corresponding 95 % confidence intervals (CI).
Analysis revealed a statistically significant difference in 5yOS concerning subgroup differences However, 10yOS and 5yMSS did not exhibit statistical significance. Nonetheless, a consistent trend emerged indicating a higher survival rate corresponding to increased immune cell density, ranging from absent TILs to brisk levels.
TILs present potential as a readily applicable prognostic factor. Yet, further investigations into their density and phenotypic subpopulation characteristics could enhance our understanding of their predictive value in tailoring optimal patient-specific therapies.
众多研究强调肿瘤浸润淋巴细胞（TILs）作为黑色素瘤重要预后因素的相关性。本荟萃分析旨在提供一份全面的文献综述，阐明其在预测患者预后中的作用，特别是研究TIL密度与预后之间的关联。
从最初的6094条记录中，筛选出16项符合纳入标准的研究，涵盖了总共16021名患者。从每项研究中提取关于TIL计数、临床特征和生存指标（5年总生存率[5yOS]、10年总生存率[10yOS]和5年黑色素瘤特异性生存率[5yMSS]）的数据，并以比例形式表示。结果用森林图以图形方式呈现，报告各独立研究的估计值、汇总估计值以及相应的95%置信区间（CI）。
分析显示，5yOS在亚组差异方面存在统计学显著差异。然而，10yOS和5yMSS未表现出统计学显著性。尽管如此，出现了一个一致的趋势，即从无TIL到活跃水平，免疫细胞密度增加对应着更高的生存率。
TILs具有作为一种易于应用的预后因素的潜力。然而，对其密度和表型亚群特征的进一步研究可能会加深我们对其在定制最佳个体化患者治疗中的预测价值的理解。
