Sharpley Christopher F, Bitsika Vicki, Christie David R H, Bradford Rosemary, Steigler Allison, Denham James W
a Brain-Behaviour Research Group , University of New England , Armidale , New South Wales , Australia.
b Centre for Autism Spectrum Disorders , Bond University , Gold Coast , Queensland , Australia.
J Psychosoc Oncol. 2017 Jul-Aug;35(4):438-450. doi: 10.1080/07347332.2017.1306733. Epub 2017 Mar 20.
Repeated surveys of prostate cancer (PCa) patients indicate that their prevalence of depression is well above that for their non-PCa peers. Although standard first-line treatments for depression are only about 35% effective, some recent comments have suggested that a focus upon the possible correlates (factors that aggravate or mediate depression) might help improve treatment efficacy. To investigate this issue, 144 10 year PCa survivors were asked about the frequency of urinary incontinence, a common side effect of some PCa treatments. The 53 patients who suffered urinary incontinence had significantly higher depression scores on the Zung Self-rating Depression Scale than those patients who did not report urinary incontinence. Using mediation analysis, patients' psychological resilience (PR) significantly mediated the depressive effects of urinary incontinence, but those effects were confined to just one of the five components of PR-a sense of control over the things that happen to oneself. Implications for treatment models of psychosocial oncology support for PCa survivors are discussed.
对前列腺癌（PCa）患者的反复调查表明，他们的抑郁症患病率远高于非PCa同龄人。尽管抑郁症的标准一线治疗仅约35%有效，但最近的一些评论表明，关注可能的相关因素（加重或介导抑郁症的因素）可能有助于提高治疗效果。为了研究这个问题，144名10年的PCa幸存者被问及尿失禁的频率，尿失禁是一些PCa治疗的常见副作用。53名患有尿失禁的患者在Zung自评抑郁量表上的抑郁得分显著高于未报告尿失禁的患者。通过中介分析，患者的心理韧性（PR）显著介导了尿失禁的抑郁效应，但这些效应仅限于PR的五个组成部分之一——对发生在自己身上的事情的控制感。讨论了对PCa幸存者心理社会肿瘤学支持治疗模式的影响。
