DNA甲基化年龄作为患有多种慢性病的癌症幸存者症状和恢复力生物标志物的可行性。
Feasibility of DNA Methylation Age as a Biomarker of Symptoms and Resilience among Cancer Survivors with Multiple Chronic Conditions.
作者信息
Lukkahatai Nada, Park Jongmin, Jia Hejingzi Monica, Martin Daniel, Li Junxin, Sheng Jennifer Yeong-Shin, Gill Jessica, Saligan Leorey N, Stearns Vered, Carducci Michael
机构信息
School of Nursing, Johns Hopkins University, Baltimore, MD 21205, USA.
College of Nursing, Research Institute of Nursing Science, Pusan National University, Yangsan-si 50612, Republic of Korea.
出版信息
Biomedicines. 2023 Nov 16;11(11):3076. doi: 10.3390/biomedicines11113076.
This study aims to examine the feasibility of DNA methylation age as a biomarker for symptoms and resilience in cancer survivors with multiple chronic conditions (MCCs). We included ten participants from our parent study, an ongoing randomized control trial study. Participants' symptoms and resilience were assessed, and peripheral blood was collected. DNA methylation age calculation was performed using DNAge analysis. Data were analyzed using Spearman's correlation analysis and the Mann-Whitney U test. Participants in the intervention group tended to have a decrease in DNA methylation age and age acceleration after completing an exercise program (mean difference = -0.83 ± 1.26). The change in DNA methylation age was significantly correlated with the change in resilience score (r = -0.897, = 0.015). The preliminary results suggest that DNA methylation age can be a potential biomarker for improving resilience in cancer survivors with multiple chronic conditions. This finding is limited by the small sample size, and a larger study is needed.
本研究旨在探讨DNA甲基化年龄作为患有多种慢性病（MCC）的癌症幸存者症状和恢复力生物标志物的可行性。我们纳入了来自我们的母研究（一项正在进行的随机对照试验研究）的10名参与者。评估了参与者的症状和恢复力，并采集了外周血。使用DNAge分析进行DNA甲基化年龄计算。使用Spearman相关分析和Mann-Whitney U检验对数据进行分析。干预组的参与者在完成一项锻炼计划后，DNA甲基化年龄和年龄加速倾向于降低（平均差异=-0.83±1.26）。DNA甲基化年龄的变化与恢复力得分的变化显著相关（r=-0.897，P=0.015）。初步结果表明，DNA甲基化年龄可能是改善患有多种慢性病的癌症幸存者恢复力的潜在生物标志物。这一发现受到样本量小的限制，需要进行更大规模的研究。
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