Department of Dermatology, Cleveland Clinic, Cleveland, Ohio; Department of Pathology, Cleveland Clinic, Cleveland, Ohio.
J Am Acad Dermatol. 2017 Jun;76(6):1176-1182. doi: 10.1016/j.jaad.2017.01.012. Epub 2017 Mar 17.
Hydroxychloroquine has unique immunomodulatory properties and an attractive adverse effect profile. Over the past 10 years, research has led to significant updates in clinical recommendations concerning the optimal use of hydroxychloroquine and monitoring of patients taking it. We discuss updated recommendations concerning hydroxychloroquine daily dosing, retinopathy screening, serologic monitoring, use in smokers, use in pregnant women, and adverse effect risk and monitoring. This review can hopefully serve as an aid to dermatologists and help ensure they continue using hydroxychloroquine safely and effectively.
羟氯喹具有独特的免疫调节特性和理想的不良反应谱。在过去的 10 年中,研究促使有关羟氯喹最佳使用和用药患者监测的临床建议得到了重大更新。我们讨论了羟氯喹日剂量、视网膜病变筛查、血清学监测、在吸烟者中的应用、在孕妇中的应用以及不良反应风险和监测的更新建议。希望这篇综述可以为皮肤科医生提供帮助,并确保他们继续安全有效地使用羟氯喹。