Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Milan, Italy.
Ophthalmological Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Clin Exp Ophthalmol. 2022 Jul;50(5):500-509. doi: 10.1111/ceo.14090. Epub 2022 May 14.
To measure quantitative autofluorescence (qAF) in patients under treatment with hydroxychloroquine (HCQ) and at risk of retinal toxicity but with no apparent signs of retinal toxicity and to compare it with that of untreated subjects.
Consecutive patients at risk for the development of HCQ retinal toxicity (duration of treatment >5 years or daily HCQ dose >5 mg/kg of actual body weight [ABW]) but no alterations on spectral domain-optical coherence tomography, short-wavelength autofluorescence and 10-2 visual field examination were recruited. Healthy subjects matched by age and sex were also enrolled in the study. All subjects underwent qAF measurements in one eye. Images were analysed using the conventional qAF grid by Delori calculating the qAF of eight sectors of the intermediate ring and the mean of those values (qAF ).
Thirty-nine patients treated with HCQ (38 females, mean age 52.1 ± 8.6 years) and 39 untreated subjects (38 females, mean age 51.2 ± 8.6 years) were included. In both HCQ patients and untreated subjects, qAF was positively correlated with age (p = 0.004). Although HCQ patients showed a higher mean qAF compared with untreated subjects (294.7 ± 65.3 vs. 268.9 ± 57.5), the difference was not significant (p = 0.068). HCQ patients showed significantly higher mean qAF values in the inferior-temporal, inferior and inferior-nasal sectors of the intermediate ring of qAF grid compared with untreated subjects (all p < 0.05).
These results suggest a possible preclinical increase of qAF values in inferior parafoveal sectors probably induced by HCQ exposure.
测量接受羟氯喹（HCQ）治疗且有视网膜毒性风险但尚无明显视网膜毒性迹象的患者的定量自发荧光（qAF），并将其与未治疗的患者进行比较。
招募有发生 HCQ 视网膜毒性风险的连续患者（治疗时间>5 年或每日 HCQ 剂量>5mg/kg 实际体重[ABW]），但在光谱域光学相干断层扫描、短波自动荧光和 10-2 视野检查中没有任何改变。还招募了年龄和性别匹配的健康受试者。所有受试者均在一只眼接受 qAF 测量。使用 Delori 的常规 qAF 网格分析图像，计算中间环的八个扇区的 qAF 和这些值的平均值（qAF）。
共纳入 39 名接受 HCQ 治疗的患者（38 名女性，平均年龄 52.1±8.6 岁）和 39 名未治疗的受试者（38 名女性，平均年龄 51.2±8.6 岁）。在 HCQ 患者和未治疗的受试者中，qAF 与年龄呈正相关（p=0.004）。尽管 HCQ 患者的平均 qAF 高于未治疗的受试者（294.7±65.3 比 268.9±57.5），但差异无统计学意义（p=0.068）。HCQ 患者的中间环 qAF 网格的下颞、下和下鼻扇区的平均 qAF 值明显高于未治疗的受试者（均 p<0.05）。
这些结果表明，在接受 HCQ 暴露后，可能在下旁中心区出现 qAF 值的临床前增加。
