初发精神分裂症的药物未治疗青少年和年轻成人中心血管代谢危险因素谱的早期出现。
Early onset of cardiometabolic risk factor profiles in drug naïve adolescents and young adults with first-episode schizophrenia.
机构信息
Xinxiang Medical University, The Second Affiliated Hospital, Xinxiang 453002, China; Xinxiang Medical University, School of Public Health, Xinxiang 453003, China.
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
出版信息
Schizophr Res. 2017 Dec;190:60-62. doi: 10.1016/j.schres.2017.03.004. Epub 2017 Mar 18.
OBJECTIVE AND METHOD
We performed a case-control study, which included antipsychotic-naïve first-episode schizophrenia (FES) of adolescents and young adults and general population controls, to investigate the early-onset cardiometabolic risk factors in FES.
RESULTS
FES had more frequent lower HDL-C when compared to controls. However, the distribution of BMI and the frequency of hypercholesterolemia, elevated LDL-C, hypertriglyceridemia in FES were not significantly different to controls.
CONCLUSIONS
The results indicated that abnormal HDL-C might be an early-onset event in drug-naïve FES of adolescents and young adults who are unlikely to have other cardiometabolic risks.
目的与方法
我们进行了一项病例对照研究，纳入了抗精神病药物初治的青少年和年轻成人首发精神分裂症（FES）患者和一般人群对照，以研究 FES 的早期心血管代谢危险因素。
结果
与对照组相比，FES 患者的 HDL-C 更低。然而，FES 患者的 BMI 分布和高胆固醇血症、升高的 LDL-C、高三酰甘油血症的发生率与对照组相比没有显著差异。
结论
研究结果表明，HDL-C 异常可能是青少年和年轻成人抗精神病药物初治 FES 的早期事件，这些患者不太可能存在其他心血管代谢风险。
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