Xinxiang Medical University, The Second Affiliated Hospital, Xinxiang 453002, China; Xinxiang Medical University, School of Public Health, Xinxiang 453003, China.
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
Schizophr Res. 2017 Dec;190:60-62. doi: 10.1016/j.schres.2017.03.004. Epub 2017 Mar 18.
We performed a case-control study, which included antipsychotic-naïve first-episode schizophrenia (FES) of adolescents and young adults and general population controls, to investigate the early-onset cardiometabolic risk factors in FES.
FES had more frequent lower HDL-C when compared to controls. However, the distribution of BMI and the frequency of hypercholesterolemia, elevated LDL-C, hypertriglyceridemia in FES were not significantly different to controls.
The results indicated that abnormal HDL-C might be an early-onset event in drug-naïve FES of adolescents and young adults who are unlikely to have other cardiometabolic risks.
我们进行了一项病例对照研究，纳入了抗精神病药物初治的青少年和年轻成人首发精神分裂症（FES）患者和一般人群对照，以研究 FES 的早期心血管代谢危险因素。
与对照组相比，FES 患者的 HDL-C 更低。然而，FES 患者的 BMI 分布和高胆固醇血症、升高的 LDL-C、高三酰甘油血症的发生率与对照组相比没有显著差异。
研究结果表明，HDL-C 异常可能是青少年和年轻成人抗精神病药物初治 FES 的早期事件，这些患者不太可能存在其他心血管代谢风险。
