Department of Child and Adolescent Psychiatry, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Krakow, Poland.
Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Krakow, Poland.
Int J Mol Sci. 2023 Jul 12;24(14):11375. doi: 10.3390/ijms241411375.
Schizophrenia is characterized by complex metabolic dysregulations and their consequences. Until now, numerous theories have explained its pathogenesis, using a spectrum of available technologies. We focused our interest on lipid profile-periphery high-density cholesterol level and lipoproteins in the human brain and compared magnetic resonance imaging (MRI) scans of patients with schizophrenia and the healthy group. Detailed analysis of biochemical parameters was performed using magnetic resonance spectroscopy. Our study aimed to reveal correlations between periphery high-density lipoproteins levels and lipoproteins in the brain, depicted in MRI scans, and parameters of peripheral oxidative stress expressed as paraoxonase. Patients with schizophrenia have decreased levels of high-density lipoproteins, low paraoxonase activity, and slightly raised sodium in the blood. Positive significant correlations between serum high-density cholesterol and anterior cingulate cortex, unique brain area for schizophrenia pathophysiology, MR spectroscopy signals, and diffusion have been revealed. To our knowledge, this is the first study to describe the effect of an anterior cingulate disorder on high-density cholesterol levels on the development of schizophrenia.
精神分裂症的特征是复杂的代谢失调及其后果。到目前为止，已有许多理论利用各种现有技术来解释其发病机制。我们将注意力集中在血脂谱——外周高密度胆固醇水平和脂蛋白上，并比较了精神分裂症患者和健康组的磁共振成像（MRI）扫描结果。使用磁共振波谱对生化参数进行了详细分析。我们的研究旨在揭示外周高密度脂蛋白水平与 MRI 扫描中显示的大脑脂蛋白之间的相关性，以及外周氧化应激参数（表现为对氧磷酶）之间的相关性。精神分裂症患者的高密度脂蛋白水平降低，对氧磷酶活性降低，血液中的钠含量略有升高。已经揭示了血清高密度胆固醇与精神分裂症病理生理学的独特大脑区域——前扣带皮层之间存在显著正相关，以及与磁共振波谱信号和扩散之间存在显著正相关。据我们所知，这是第一项描述前扣带紊乱对精神分裂症发展过程中高密度胆固醇水平影响的研究。
