人胃底黏膜中胃蛋白酶原A基因的低甲基化与表达
Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.
作者信息
Ichinose M, Miki K, Tatematsu M, Furihata C, Nobuhara M, Ichihara Y, Tanji M, Sogawa K, Fujii-Kuriyama Y, Oka H
机构信息
Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan.
出版信息
Biochem Biophys Res Commun. 1988 Feb 29;151(1):275-82. doi: 10.1016/0006-291x(88)90590-6.
We have examined the correlation between the extents of methylation and expression of pepsinogen A genes in normal human tissues. Expression of pepsinogen A mRNA was detected only in the fundic mucosa of the stomach and both CCGG and GCGC sites in the genes region were less methylated in the fundic mucosa than in other non-expressing tissues. Thus, there was an inverse correlation between the extents of methylation and expression of pepsinogen A genes and the role of DNA methylation in the regulation of pepsinogen A genes expression during normal differentiation was suggested.
我们研究了正常人组织中胃蛋白酶原A基因的甲基化程度与表达之间的相关性。仅在胃底黏膜中检测到胃蛋白酶原A mRNA的表达，并且该基因区域中的CCGG和GCGC位点在胃底黏膜中的甲基化程度低于其他非表达组织。因此，胃蛋白酶原A基因的甲基化程度与表达之间呈负相关，提示DNA甲基化在正常分化过程中胃蛋白酶原A基因表达调控中的作用。
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