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青少年超高精神病风险中，与程序学习损伤相关的自述性睡眠障碍。

Self-reported sleep disturbances associated with procedural learning impairment in adolescents at ultra-high risk for psychosis.

机构信息

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States.

Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States; Center for Neuroscience, University of Colorado Boulder, Boulder, CO, United States.

出版信息

Schizophr Res. 2017 Dec;190:160-163. doi: 10.1016/j.schres.2017.03.025. Epub 2017 Mar 16.

DOI:10.1016/j.schres.2017.03.025
PMID:28318840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5600637/
Abstract

Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased self-reported problems with sleep latency, efficiency, and quality were associated with impaired procedural learning rate. Further, within-sample comparisons revealed that UHR youth reporting better sleep displayed a steeper learning curve than those with poorer sleep. Sleep disturbances appear to contribute to cognitive/motor deficits in the UHR period and may play a role in psychosis etiology.

摘要

睡眠障碍会导致精神分裂症患者程序性学习受损，但在精神病发作前，人们对此知之甚少。有精神病超高风险（UHR；N=62）的青少年完成了匹兹堡睡眠质量指数（PSQI）和程序性学习任务（追踪旋转器）。自我报告的入睡潜伏期、效率和质量问题增加与程序性学习率受损有关。此外，样本内比较显示，报告睡眠质量较好的 UHR 青少年的学习曲线比睡眠质量较差的青少年更为陡峭。睡眠障碍似乎会导致 UHR 期间的认知/运动缺陷，并可能在精神病发病机制中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ad/5600637/06b76f1d3b68/nihms860829f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ad/5600637/4e2b8b4e8e8e/nihms860829f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ad/5600637/06b76f1d3b68/nihms860829f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ad/5600637/4e2b8b4e8e8e/nihms860829f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9ad/5600637/06b76f1d3b68/nihms860829f2.jpg

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