Boonsiriseth K, Latt M M, Kiattavorncharoen S, Pairuchvej V, Wongsirichat N
Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand; Insein General Hospital, Insein Township, Yangon, Myanmar.
Int J Oral Maxillofac Surg. 2017 Jul;46(7):899-904. doi: 10.1016/j.ijom.2017.02.1266. Epub 2017 Mar 16.
The objective of this study was to evaluate the effects of 8mg dexamethasone injection into the pterygomandibular space on the postoperative sequelae of lower third molar surgery. A prospective, randomized, controlled, split-mouth study was designed involving 62 lower third molar extractions (31 patients). Prior to surgery, the study group received 2ml of 4mg/ml (8mg) dexamethasone injection through the pterygomandibular space following local anaesthesia; the control group received 2ml normal saline injection. Facial swelling, mouth opening, pain on a visual analogue scale (VAS), and the number of analgesics consumed were assessed. Descriptive statistics and the independent-samples t-test were used to compare the two groups at P<0.05. There was a significant reduction in swelling on day 2 postoperative in the dexamethasone group. Mouth opening was also significantly greater on day 2 in the dexamethasone group. The VAS pain score was significantly lower on the day of the operation and first postoperative day in the dexamethasone group, but did not differ significantly between the groups on the other postoperative days. The injection of 8mg dexamethasone into the pterygomandibular space was effective in reducing postoperative swelling, limited mouth opening, and pain following impacted lower third molar extraction.
本研究的目的是评估在翼下颌间隙注射8毫克地塞米松对下颌第三磨牙手术后后遗症的影响。设计了一项前瞻性、随机、对照、双侧对照研究，纳入62例下颌第三磨牙拔除术（31例患者）。手术前，研究组在局部麻醉后通过翼下颌间隙注射2毫升4毫克/毫升（8毫克）地塞米松；对照组注射2毫升生理盐水。评估面部肿胀、开口度、视觉模拟评分法（VAS）疼痛评分以及镇痛药的使用数量。采用描述性统计和独立样本t检验对两组进行比较，P<0.05。地塞米松组术后第2天肿胀明显减轻。地塞米松组术后第2天的开口度也明显更大。地塞米松组在手术当天和术后第1天的VAS疼痛评分明显更低，但在其他术后天数两组之间无显著差异。在翼下颌间隙注射8毫克地塞米松可有效减轻下颌阻生第三磨牙拔除术后的肿胀、开口受限和疼痛。
