Department of Dentistry University of Pernambuco Tabatinga, Camaragibe, Pernambuco, Zip Code: 54.756-220
Med Oral Patol Oral Cir Bucal. 2019 Nov 1;24(6):e746-e751. doi: 10.4317/medoral.23095.
The aim of this study was to compare the anti-inflammatory effects of dexamethasone and etoricoxib after third molar extraction.
A prospective, randomized, controlled, split-mouth study was conducted. 19 volunteers were allocated randomly to receive 90mg etoricoxib 1 hour prior to the procedure or 4mg intramuscular dexamethasone immediately after anesthesia. Baseline measurements were obtained preoperatively, and subsequent assessments were made on immediate postoperative, at 72 hours and 7 days after surgery to measure postoperative facial swelling by use of linear measurements, interincisal mouth opening width and visual analog scale score for pain. The amount of analgesics consumed was recorded. Descriptive statistics and the independent-samples t-test were used to compare the two groups at P < 0.05.
Dexamethasone was effective in the control roasted edema for measurements of the mandibular angle - wing of the nose and mandibular angle - labial commissure 72 hours after surgery. And for the measurement mandibular angle - mentum, in the time of 72 hours and 7 days. There was no statistically significant difference in relation to pain and trismus.
Considering significant results for some measures of the variable edema for the group that used intramuscular dexamethasone and the difference without statistical significance between groups for the other variables studied, we seem to reflect the intramuscular indication of the corticosteroid in a single dosage in relation to the use of etoricoxib as pre-emptive medication.
本研究旨在比较地塞米松和依托考昔在第三磨牙拔除术后的抗炎效果。
采用前瞻性、随机、对照、分侧研究。19 名志愿者随机分配，在手术前 1 小时给予 90mg 依托考昔或在麻醉后立即给予 4mg 肌肉注射地塞米松。术前测量基线，术后即刻、72 小时和 7 天进行后续评估，通过线性测量、切牙开口宽度和疼痛视觉模拟评分来测量术后面部肿胀，记录镇痛药的消耗量。采用描述性统计和独立样本 t 检验比较两组，P < 0.05。
地塞米松对下颌角-鼻翼和下颌角-唇联合的术后 72 小时测量结果有效控制了肿胀。对于下颌角-颏部的测量，在 72 小时和 7 天的时间点。在疼痛和张口度方面，两组间无统计学差异。
考虑到使用肌肉注射地塞米松组在某些肿胀变量的测量中出现了显著的结果，而在其他研究变量中，两组间的差异无统计学意义，因此我们似乎可以反映出在单次剂量肌肉注射皮质类固醇与使用依托考昔作为预防性药物之间的关系。
