芳香烃受体（AHR）和缺氧诱导因子-1α（HIF-1α）在胶质母细胞瘤代谢中的作用。
Role of AHR and HIF-1α in Glioblastoma Metabolism.
作者信息
Gabriely Galina, Wheeler Michael A, Takenaka Maisa C, Quintana Francisco J
机构信息
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
出版信息
Trends Endocrinol Metab. 2017 Jun;28(6):428-436. doi: 10.1016/j.tem.2017.02.009. Epub 2017 Mar 16.
Glioblastoma (GBM) progression is associated with metabolic remodeling in both glioma and immune cells, resulting in the use of aerobic glycolysis as the main source of energy and biosynthetic molecules. The transcription factor hypoxia-inducible factor (HIF)-1α drives this metabolic reorganization. Oxygen levels, as well as other factors, control the activity of HIF-1α. In addition, the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) modulates tumor-specific immunity and can also participate in metabolic remodeling. AHR activity is regulated by tryptophan derivatives present in the tumor microenvironment. Thus, the tumor microenvironment and signaling via HIF-1α and AHR regulate the metabolism of gliomas and immune cells, modulating tumor-specific immunity and, consequently, tumor growth. Here, we review the roles of HIF-1α and AHR in cancer and immune cell metabolism in GBM.
胶质母细胞瘤（GBM）的进展与胶质瘤细胞和免疫细胞中的代谢重塑相关，导致有氧糖酵解成为能量和生物合成分子的主要来源。转录因子缺氧诱导因子（HIF）-1α驱动这种代谢重组。氧水平以及其他因素控制HIF-1α的活性。此外，配体激活的转录因子芳烃受体（AHR）调节肿瘤特异性免疫，也可参与代谢重塑。AHR的活性受肿瘤微环境中存在的色氨酸衍生物调节。因此，肿瘤微环境以及通过HIF-1α和AHR的信号传导调节胶质瘤和免疫细胞的代谢，调节肿瘤特异性免疫，进而影响肿瘤生长。在此，我们综述了HIF-1α和AHR在GBM的癌症和免疫细胞代谢中的作用。
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