CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
Trends Biochem Sci. 2017 Jun;42(6):443-456. doi: 10.1016/j.tibs.2017.02.009. Epub 2017 Mar 16.
Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes, has emerged as a major health concern. ZIKV infections can cause serious neurological complications in adults, and infection in pregnant women can cause congenital malformations, including fetal and newborn microcephaly. In response to this emerging concern, the structural virology field was quick to explore the features of ZIKV. These efforts have provided significant insights into ZIKV pathogenesis, and have identified targets for drug design. Here, we review the remarkable progress in structure-based ZIKV research and discuss the current challenges and future opportunities.
寨卡病毒（ZIKV）是黄病毒科的一种成员，通过蚊子传播给人类，已成为一个主要的健康关注点。ZIKV 感染可导致成年人严重的神经系统并发症，孕妇感染可导致先天性畸形，包括胎儿和新生儿小头畸形。为应对这一新兴问题，结构病毒学领域迅速探索了 ZIKV 的特征。这些努力为 ZIKV 发病机制提供了重要的见解，并确定了药物设计的靶点。在这里，我们回顾了基于结构的 ZIKV 研究的显著进展，并讨论了当前的挑战和未来的机遇。
