Pothupitiya G M, Wojnarowska F, Bhogal B S, Black M M
Department of Dermatology, Slade Hospital, Oxford, U.K.
Br J Dermatol. 1988 Feb;118(2):175-82. doi: 10.1111/j.1365-2133.1988.tb01771.x.
The tissue distribution and species expression of the antigens in adult linear IgA disease (LAD) and chronic bullous dermatosis of childhood (CBDC) was studied and compared with those of bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA) antigens. Positive sera from five adult LAD patients, 15 CBDC patients, three BP patients and two EBA patients were studied, using skin and mucosal tissues of humans and animals as substrates. The tissue distribution and phylogenetic distribution of adult LAD antigen and CBDC antigen were the same, suggesting that they are identical diseases. The antigens were both demonstrable only in stratified squamous epithelia and amnion of mammalian species. They were absent from transitional and columnar epithelium. The EBA antigen was not expressed in pig tissues or human placenta, unlike adult LAD and CBDC antigens. Expression of adult LAD, CBDC and BP antigens was observed in all tissues except bladder, which lacked LAD and CBDC antigens. These results suggest that the antigens in adult LAD and CBDC are the same and differ from EP and EBA antigens.
研究了成人线状IgA疾病（LAD）和儿童慢性大疱性皮肤病（CBDC）中抗原的组织分布和物种表达，并将其与大疱性类天疱疮（BP）和获得性大疱性表皮松解症（EBA）抗原进行比较。使用人和动物的皮肤及黏膜组织作为底物，对5例成人LAD患者、15例CBDC患者、3例BP患者和2例EBA患者的阳性血清进行了研究。成人LAD抗原和CBDC抗原的组织分布及种系发生分布相同，提示它们是同一种疾病。这些抗原仅在哺乳动物的复层鳞状上皮和羊膜中可检测到，在移行上皮和柱状上皮中不存在。与成人LAD和CBDC抗原不同，EBA抗原在猪组织或人胎盘中不表达。除膀胱缺乏LAD和CBDC抗原外，在所有组织中均观察到成人LAD、CBDC和BP抗原的表达。这些结果表明，成人LAD和CBDC中的抗原相同，且与EP和EBA抗原不同。
