Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Barcelona, Spain.
Departament de Farmacologia, de Terapèutica i de Toxicologia, Institut de Neurociències, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201601010. Epub 2017 Apr 5.
Sofrito, a key component of the Mediterranean diet, provides nutritional interest due to its high content in bioactive compounds from tomato and olive oil, and especially to the lipid matrix in which these compounds are found. In this study, the potential beneficial effects of dietary intake of sofrito on obesity-related vascular alterations were explored in obese Zucker rats.
Obese and lean rats were fed a control diet supplemented or not with 2% w/w sofrito for 8 weeks. Vascular function was evaluated in aorta in organ baths. Dihydroethidium staining and immunofluorescence was used to determine aortic superoxide and peroxynitrite production, respectively. Despite food and caloric intake was higher in sofrito-fed obese rats, no differences were appreciated on body weight compared to control rats. Sofrito attenuated phenylephrine-induced vasoconstriction. This effect was associated with preservation of nitric oxide on vasoconstriction and normalization of serum nitric oxide metabolites, vascular inducible nitric oxide synthase and vascular superoxide and peroxynitrite levels.
This is the first evidence of tomato-based sofrito protection against vascular alterations that could precede major cardiometabolic complications in obesity. These results contribute to explain the therapeutic properties of the Mediterranean diet in obesity-related disorders. Therefore, sofrito is an attractive dietary approach against vascular alterations in obesity.
Sofrito 是地中海饮食的一个重要组成部分，由于其富含番茄和橄榄油中的生物活性化合物，尤其是这些化合物所在的脂质基质，因此具有营养价值。本研究旨在探讨膳食摄入 Sofrito 对肥胖相关血管改变的潜在有益作用。
肥胖和瘦 Zucker 大鼠分别喂食对照饮食或补充 2% w/w Sofrito 的对照饮食 8 周。在器官浴中评估主动脉血管功能。二氢乙啶染色和免疫荧光法分别用于测定主动脉中超氧化物和过氧亚硝酸盐的产生。尽管 Sofrito 喂养的肥胖大鼠的食物和热量摄入较高，但与对照组相比，体重无差异。Sofrito 减轻了去甲肾上腺素引起的血管收缩。这种作用与血管收缩时一氧化氮的保留以及血清一氧化氮代谢物、血管诱导型一氧化氮合酶和血管超氧化物和过氧亚硝酸盐水平的正常化有关。
这是番茄基 Sofrito 预防肥胖相关血管改变的首个证据，这些改变可能先于肥胖相关心血管代谢并发症的发生。这些结果有助于解释地中海饮食在肥胖相关疾病中的治疗特性。因此，Sofrito 是一种针对肥胖血管改变的有吸引力的饮食方法。
