Rinaldi de Alvarenga José Fernando, Garcia-Aloy Mar, Ulaszewska Marynka, Zagmutt Sebastian, Perez-Montero Marta, Vrhovsek Urska, Lamuela-Raventós Rosa M, Rodriguez-Rodriguez Rosalia
Human Nutrition Unit, Department of Food & Drug, University of Parma, 43124 Parma, Italy.
Food Research Center (FoRC), University of São Paulo, Rua do Lago 250, São Paulo 05508-080, Brazil.
Antioxidants (Basel). 2022 Oct 31;11(11):2165. doi: 10.3390/antiox11112165.
The increasing prevalence of obesity worldwide has promoted research on human metabolism and foods such as , a tomato and olive oil-based sauce from the Mediterranean diet, has shown beneficial effects on obesity and related complications. has been associated with better cardiovascular health, metabolic syndrome, and anti-inflammatory effects. The aim of this study was to understand how intake could contribute to the control of energy metabolism in obese rats. For this purpose, integrative untargeted lipidomics, metabolomics, and targeted gene expression approaches were used in the liver and adipose tissue to identify metabolic changes and the mechanism of action promoted by intake. A new biomarker was identified in the liver, butanediol glucuronide, an indicator of ketogenic activation and lipid oxidation after the intervention. Gene expression analysis revealed an increase in the uptake and liver oxidation of lipids for energy production and ketogenesis activation as fuel for other tissues in -fed animals. altered the lipidomic profile in the fat depots of obese rats. This multiomics study identifies a new biomarker linked to the beneficial actions of against obesity and provides further insight into the beneficial effect of the Mediterranean diet components.
全球肥胖率的不断上升推动了对人体新陈代谢的研究，诸如一种源自地中海饮食的以番茄和橄榄油为基础的酱料，已显示出对肥胖及相关并发症有有益影响。它与更好的心血管健康、代谢综合征及抗炎作用相关。本研究的目的是了解该酱料的摄入如何有助于控制肥胖大鼠的能量代谢。为此，在肝脏和脂肪组织中采用了综合非靶向脂质组学、代谢组学及靶向基因表达方法，以识别代谢变化及该酱料摄入所促进的作用机制。在肝脏中鉴定出一种新的生物标志物，丁二醇葡糖醛酸，它是该酱料干预后生酮激活和脂质氧化的指标。基因表达分析显示，在摄入该酱料的动物中，脂质的摄取及肝脏氧化增加，以产生能量并激活生酮作用，为生酮作为其他组织的燃料。该酱料改变了肥胖大鼠脂肪库中的脂质组学特征。这项多组学研究鉴定出一种与该酱料对抗肥胖的有益作用相关的新生物标志物，并进一步深入了解了地中海饮食成分的有益作用。
