Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, United Kingdom.
Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, United Kingdom.
Curr Opin Immunol. 2017 Apr;45:103-111. doi: 10.1016/j.coi.2017.03.001. Epub 2017 Mar 17.
Secondary lymphoid organs are organized into distinct zones, governed by different types of mesenchymal stromal cells. These stromal cell subsets are critical for the generation of protective humoral immunity because they direct the migration of, and interaction between, multiple immune cell types to form the germinal centre. The germinal centre response generates long-lived antibody-secreting plasma cells and memory B cells which can provide long-term protection against re-infection. Stromal cell subsets mediate this response through control of immune cell trafficking, activation, localization and antigen access within the secondary lymphoid organ. Further, distinct populations of stromal cells underpin the delicate spatial organization of immune cells within the germinal centre. Because of this, the interactions between immune cells and stromal cells in secondary lymphoid organs are fundamental to the germinal centre response. Herein we review how this unique relationship leads to effective germinal centre responses.
次级淋巴器官组织成不同的区域，由不同类型的间质基质细胞控制。这些基质细胞亚群对于产生保护性体液免疫至关重要，因为它们指导多种免疫细胞类型的迁移和相互作用，形成生发中心。生发中心反应产生长寿的抗体分泌浆细胞和记忆 B 细胞，可提供针对再次感染的长期保护。基质细胞亚群通过控制次级淋巴器官中免疫细胞的迁移、激活、定位和抗原摄取来介导这种反应。此外，生发中心内免疫细胞的精细空间组织依赖于不同的基质细胞群体。因此，次级淋巴器官中免疫细胞和基质细胞之间的相互作用是生发中心反应的基础。本文综述了这种独特的关系如何导致有效的生发中心反应。
