Gano Anny, Doremus-Fitzwater Tamara L, Deak Terrence
Behavioral Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY, USA.
Department of Psychology, Ithaca College, Ithaca, NY, USA.
Neurobiol Aging. 2017 Jun;54:40-53. doi: 10.1016/j.neurobiolaging.2017.01.025. Epub 2017 Mar 17.
Our work in Sprague Dawley rats has shown rapid alterations in neuroimmune gene expression (RANGE) in the hippocampus and paraventricular nucleus of the hypothalamus (PVN). These manifest as increased interleukin (IL)-6 and IκBα, and suppressed IL-1β and tumor necrosis factor alpha during acute ethanol intoxication. The present studies tested these effects across the lifespan (young adulthood at 2-3 months; senescence at 18 and 24 months), as well as across strain (Fischer 344) and sex. The hippocampus revealed age-dependent shifts in cytokine expression (IL-6, IL-1β, and monocyte chemoattractant protein 1), but no changes were observed in the PVN at baseline or following ethanol. RANGE in adults was similar across sex and comparable with effects seen in Sprague Dawley rats. Plasma corticosterone levels increased with age, whereas the blood ethanol concentrations and loss of righting reflex were similar in all groups older than 2 months. These findings indicate that the RANGE effect is largely conserved across strain and is durable across age, even in the face of a shifting neuroimmune profile that emerges during immunosenescence.
我们在斯普拉格-道利大鼠身上的研究表明，海马体和下丘脑室旁核（PVN）中存在神经免疫基因表达的快速变化（RANGE）。在急性乙醇中毒期间，这些变化表现为白细胞介素（IL）-6和IκBα增加，而IL-1β和肿瘤坏死因子α受到抑制。本研究在整个生命周期（2 - 3个月的青年期；18个月和24个月的衰老期）以及不同品系（Fischer 344）和性别中测试了这些影响。海马体显示出细胞因子表达（IL-6、IL-1β和单核细胞趋化蛋白1）的年龄依赖性变化，但在基线时或乙醇处理后，PVN中未观察到变化。成年期的RANGE在性别上相似，且与在斯普拉格-道利大鼠中观察到的效应相当。血浆皮质酮水平随年龄增加，而在所有2个月以上的组中，血液乙醇浓度和翻正反射丧失情况相似。这些发现表明，RANGE效应在很大程度上在不同品系中是保守的，并且在整个年龄范围内都是持久的，即使面对免疫衰老过程中出现的不断变化的神经免疫特征。
