Asian Network of Research on Antidiabetic Plants (ANRAP), Bangladesh University of Health Science, Mirpur, Dhaka 1216, Bangladesh.
Department of Pharmacy, Xinhua College of Sun Yat-sen University,Tianhe District, Guangzhou 510520, China.
Biomed Pharmacother. 2017 May;89:1242-1251. doi: 10.1016/j.biopha.2017.03.010. Epub 2017 Mar 17.
Type 2 diabetes mellitus is a complex and heterogeneous disorder which in its most common manifestation arises from insulin resistance and later insulin insufficiency. Type 2 diabetes is characterised by impaired insulin sensitivity and diagnosed as hyperglycaemia. Because of its cardiovascular consequences, Type 2 diabetes represents one of the world's leading causes of mortality and morbidity. Drug discovery and development are required to produce better ways to prevent, treat and manage diabetes and its complications. Diabetes is a human, not an animal disease, so animals do not get Type 2 diabetes. However there are animal models which are variously suitable for the investigation of new agents for the treatment of Type 2 diabetes. In this Review we have examined the various models that are available for the study of natural products with a focus on models (genetic, nutritional and spontaneous) for the metabolic abnormities of diabetes. These models are also relevant to the investigation of Western medicines for the treatment of diabetes. A suitable experimental model plays an important role in drug discovery for translational studies leading to increased understanding of the molecular basis and management of diabetes.
2 型糖尿病是一种复杂的异质性疾病，其最常见的表现形式是胰岛素抵抗和随后的胰岛素不足。2 型糖尿病的特征是胰岛素敏感性受损，诊断为高血糖。由于其心血管后果，2 型糖尿病是世界上主要的死亡和发病原因之一。需要进行药物发现和开发，以产生更好的方法来预防、治疗和管理糖尿病及其并发症。糖尿病是一种人类疾病，而不是动物疾病，因此动物不会患 2 型糖尿病。但是，有各种动物模型可用于研究治疗 2 型糖尿病的新药物。在这篇综述中，我们检查了可用于研究天然产物的各种模型，重点是（遗传、营养和自发）用于研究糖尿病代谢异常的模型。这些模型也与治疗糖尿病的西药研究有关。合适的实验模型在导致对糖尿病的分子基础和管理有更深入理解的转化研究药物发现中发挥着重要作用。
