[禽成髓细胞瘤病毒诱导雏鸡脑膜肿瘤]
[Induction of tumors of the meningeal membranes in chicks by the avian myeloblastosis virus].
作者信息
Tiufanov A V
出版信息
Biull Eksp Biol Med. 1988 Mar;105(3):318-22.
The meningiomas could be easily produced by intracerebral injection of the avian myeloblastosis virus (0.01 ml of virus suspension with titer 10(9)-10(12) PFU/ml) into highly susceptible (White Leghorn Anya cross) or randomly bred newborn (24-48 hours) chicken. Tumours were observed in 66.7% highly susceptible chickens and in 33.73% of randomly bred chickens. First clinical signs of disease appeared on the 7-9th days after infection. Death occurred on the 3-4th days after beginning of the disease. Five types of tumours were detected: meningotheliomatous, fibroblastic, angiomatous, mixed and anaplastic. Our data are first description of the tumours of CNS induced by the avian myeloblastosis virus.
通过向高度易感（白来航鸡与安雅鸡杂交品种）或随机繁殖的新生（24 - 48小时）鸡脑内注射禽成髓细胞瘤病毒（0.01毫升滴度为10(9)-10(12) PFU/毫升的病毒悬液），可轻易诱发脑膜瘤。在66.7%的高度易感鸡和33.73%的随机繁殖鸡中观察到肿瘤。感染后第7 - 9天出现疾病的最初临床症状。疾病开始后第3 - 4天死亡。检测到五种类型的肿瘤：脑膜瘤型、纤维瘤型、血管瘤型、混合型和间变性。我们的数据是对禽成髓细胞瘤病毒诱导的中枢神经系统肿瘤的首次描述。
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