Tiufanov A V
Biull Eksp Biol Med. 1987 Aug;104(8):215-8.
A series of experiments on the induction of tumours in the central nervous system with the help of avian myeloblastosis virus was carried out. 142 highly sensitive and inbred chickens, 1 or 2 days of age, were used. The intracerebral virus dose was 0.01-0.02 ml. The titer was 10(9)--10(12) PFU/ml. 25 tumours of choroid plexus were induced during the experiments, 3 tumours developed in the control after intravenous inoculation. Out of 33 chickens highly sensitive to AMV tumours of choroid plexus were found in 6 (15.1%), and out of 75 inbred chickens tumours were found in 16 (21.3%). Three main stages of experimental tumours development in the brain choroid plexus were identified and their pathomorphological description was given. A relatively big amount of choroid plexus tumours have developed upon the brain inoculation with avian myeloblastosis virus. This might be attributed to blastomogenic virus action.
进行了一系列借助禽成髓细胞瘤病毒在中枢神经系统诱导肿瘤的实验。使用了142只1或2日龄的高度敏感近交系鸡。脑内病毒剂量为0.01 - 0.02毫升。滴度为10(9)--10(12) PFU/毫升。实验期间诱导出25个脉络丛肿瘤，静脉接种的对照组中有3个肿瘤发生。在对禽成髓细胞瘤病毒高度敏感的33只鸡中，发现6只（15.1%）有脉络丛肿瘤，在75只近交系鸡中，发现16只（21.3%）有肿瘤。确定了脑脉络丛实验性肿瘤发展的三个主要阶段并给出了它们的病理形态学描述。经脑接种禽成髓细胞瘤病毒后出现了相对大量的脉络丛肿瘤。这可能归因于致瘤病毒的作用。
