Khaspekov L G, Frumkina L E
Research Center of Neurology, Department of Brain Research, Moscow, 105064, Russia.
Biochemistry (Mosc). 2017 Mar;82(3):380-391. doi: 10.1134/S0006297917030178.
In this review we summarize published data on the involvement of glial cells in molecular mechanisms underlying brain plastic reorganization in epilepsy. The role of astrocytes as glial elements in pathological plasticity in epilepsy is discussed. Data on the involvement of aquaporin-4 in epileptogenic plastic changes and on participation of microglia and extracellular matrix in dysregulation of synaptic transmission and plastic remodeling in epileptic brain tissue are reviewed.
在本综述中，我们总结了已发表的关于胶质细胞参与癫痫大脑可塑性重组潜在分子机制的数据。讨论了星形胶质细胞作为胶质成分在癫痫病理可塑性中的作用。综述了水通道蛋白4参与致痫性可塑性变化以及小胶质细胞和细胞外基质参与癫痫脑组织突触传递失调和可塑性重塑的数据。
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