细胞骨架在成人癫痫发生中的产后作用。

Gavrilovici Cezar, Jiang Yulan, Kiroski Ivana, Teskey G Campbell, Rho Jong M, Nguyen Minh Dang

Departments of Neurosciences & Pediatrics, University of California San Diego, Rady Children's Hospital San Diego, San Diego, CA 92123, USA.

Departments of Clinical Neurosciences, Cell Biology & Anatomy, and Biochemistry & Molecular Biology, Hotchkiss Brain Institute, Alberta Children Hospital Research Institute, University of Calgary, Calgary T2N 4N1, Canada.

Cereb Cortex Commun. 2020;1(1):tgaa024. doi: 10.1093/texcom/tgaa024. Epub 2020 Jun 17.

Mutations in cytoskeletal proteins can cause early infantile and childhood epilepsies by misplacing newly born neurons and altering neuronal connectivity. In the adult epileptic brain, cytoskeletal disruption is often viewed as being secondary to aberrant neuronal activity and/or death, and hence simply represents an epiphenomenon. Here, we review the emerging evidence collected in animal models and human studies implicating the cytoskeleton as a potential causative factor in adult epileptogenesis. Based on the emerging evidence, we propose that cytoskeletal disruption may be an important pathogenic mechanism in the mature epileptic brain.

细胞骨架蛋白的突变可通过使新生神经元错位和改变神经元连接来导致早期婴儿和儿童癫痫。在成年癫痫患者的大脑中，细胞骨架破坏通常被视为继发于异常的神经元活动和/或死亡，因此仅仅是一种附带现象。在此，我们回顾了在动物模型和人体研究中收集到的新证据，这些证据表明细胞骨架是成年癫痫发生的潜在致病因素。基于这些新证据，我们提出细胞骨架破坏可能是成熟癫痫大脑中的一种重要致病机制。