Gao Ping, Jing Lili, Huang Hai, Zhang Cuiping, Hao Junmei
Department of Pathology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Jinbu Street, Yantai, Shandong Province, 264100, China.
Diagn Pathol. 2017 Mar 20;12(1):30. doi: 10.1186/s13000-017-0617-4.
Eruptive collagenoma is a rare disease. All of the previously reported cases were located on the skin. Here we report such a case occurring in esophagus and intestine.
Our patient is a Chinese woman. Two years ago, hundreds of small nodules were identified in her esophagus and intestine. The lesions were characterized by thickened hyalinized collagen fibers and haphazard neoplastic stellate cells. The tumor cells showed generally positive for vimentin and negative for h-CALD, CD34, desmin, CD163, AE1/AE3, CK7 and CK20. The nodules were blue with Masson Trichrome stain. The clinicopathological, immunohistochemical and histochemical features of the tumor were consistent with eruptive collagenoma. The patient was not given specific treatment after diagnosis, and a routine examination indicated that there was no progress for 2 years.
Hitherto, this is the first case of eruptive collagenoma to have been reported occurring in esophagus and intestine.
爆发性胶原瘤是一种罕见疾病。既往所有报道的病例均位于皮肤。在此，我们报告一例发生于食管和肠道的此类病例。
我们的患者是一名中国女性。两年前，在她的食管和肠道中发现了数百个小结节。病变的特征为胶原纤维玻璃样变增厚以及肿瘤性星状细胞排列紊乱。肿瘤细胞波形蛋白通常呈阳性，而人钙结合蛋白（h-CALD）、CD34、结蛋白、CD163、AE1/AE3、细胞角蛋白7（CK7）和细胞角蛋白20（CK20）呈阴性。结节经马松三色染色呈蓝色。肿瘤的临床病理、免疫组化和组织化学特征与爆发性胶原瘤相符。该患者诊断后未接受特殊治疗，常规检查显示2年来病情无进展。
迄今为止，这是首例报道的发生于食管和肠道的爆发性胶原瘤病例。
