一种携带多种抗菌抗性和毒力基因的新型杂交质粒存在于肠炎沙门氏菌都柏林血清型中。
A Novel Hybrid Plasmid Carrying Multiple Antimicrobial Resistance and Virulence Genes in Salmonella enterica Serovar Dublin.
作者信息
Mangat Chand S, Bekal Sadjia, Irwin Rebecca J, Mulvey Michael R
机构信息
National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Laboratoire de santé publique du Québec, Saint-Anne-de-Bellevue, Quebec, Canada.
出版信息
Antimicrob Agents Chemother. 2017 May 24;61(6). doi: 10.1128/AAC.02601-16. Print 2017 Jun.
Abstract
Virulence plasmids and antibiotic resistance plasmids are usually maintained separately in spp.; however, we report an instance of a hybrid plasmid (pN13-01125) in serovar Dublin. Review of the complete sequence of the 172,265-bp plasmid suggests that pN13-01125 is comprised of the previously described pSDVr and pSH696_135 plasmids and that the mechanism of hybridization likely involves IS (IS) insertion sequence elements. The plasmid has a low conjugation frequency, confers resistance to six classes of antimicrobials, and contains a complete virulence operon.
摘要
毒力质粒和抗生素抗性质粒通常在 种中分别维持；然而，我们报道了都柏林血清型中一个杂交质粒（pN13 - 01125）的实例。对这个172,265碱基对质粒的完整序列进行分析表明，pN13 - 01125由先前描述的pSDVr和pSH696_135质粒组成，并且杂交机制可能涉及IS（插入序列）元件。该质粒具有低接合频率，赋予对六类抗菌药物的抗性，并包含一个完整的 毒力操纵子。 （注：原文中部分 处信息缺失）
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