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1
Structural and Chemical Biology of Presenilin Complexes.
Cold Spring Harb Perspect Med. 2017 Dec 1;7(12):a024067. doi: 10.1101/cshperspect.a024067.
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Toward the structure of presenilin/γ-secretase and presenilin homologs.
Biochim Biophys Acta. 2013 Dec;1828(12):2886-97. doi: 10.1016/j.bbamem.2013.04.015.
3
Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
Int J Mol Sci. 2021 Dec 18;22(24):13600. doi: 10.3390/ijms222413600.
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Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.
J Alzheimers Dis. 2017;56(4):1263-1269. doi: 10.3233/JAD-161094.
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Structural biology of presenilin 1 complexes.
Mol Neurodegener. 2014 Dec 18;9:59. doi: 10.1186/1750-1326-9-59.
8
Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Biochemistry. 2011 Jun 7;50(22):4973-80. doi: 10.1021/bi200026m. Epub 2011 May 13.
9
Assembly of the presenilin γ-/ε-secretase complex.
J Neurochem. 2012 Jan;120 Suppl 1:84-88. doi: 10.1111/j.1471-4159.2011.07505.x. Epub 2011 Nov 28.
10
Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
J Biol Chem. 2015 Mar 13;290(11):7169-84. doi: 10.1074/jbc.M114.601286. Epub 2015 Jan 22.

引用本文的文献

2
Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease.
Neuron. 2023 Oct 18;111(20):3176-3194.e7. doi: 10.1016/j.neuron.2023.07.005. Epub 2023 Aug 4.
3
Relationship Between Amyloid-β Deposition and Blood-Brain Barrier Dysfunction in Alzheimer's Disease.
Front Cell Neurosci. 2021 Jul 19;15:695479. doi: 10.3389/fncel.2021.695479. eCollection 2021.
5
Contextual Regulation of Skeletal Physiology by Notch Signaling.
Curr Osteoporos Rep. 2019 Aug;17(4):217-225. doi: 10.1007/s11914-019-00516-y.
6
Antibody Therapeutics Targeting Aβ and Tau.
Cold Spring Harb Perspect Med. 2017 Oct 3;7(10):a024331. doi: 10.1101/cshperspect.a024331.
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Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease.
Cold Spring Harb Perspect Med. 2017 Jun 1;7(6):a024539. doi: 10.1101/cshperspect.a024539.

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1
Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.
Cell. 2016 Jun 30;166(1):193-208. doi: 10.1016/j.cell.2016.05.020. Epub 2016 Jun 9.
2
4
An atomic structure of human γ-secretase.
Nature. 2015 Sep 10;525(7568):212-217. doi: 10.1038/nature14892. Epub 2015 Aug 17.
5
Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment.
Mol Psychiatry. 2015 Oct;20(10):1179-87. doi: 10.1038/mp.2015.74. Epub 2015 Jun 9.
6
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
ACS Med Chem Lett. 2015 Apr 3;6(5):596-601. doi: 10.1021/acsmedchemlett.5b00070. eCollection 2015 May 14.
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Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Neuron. 2015 Mar 4;85(5):967-81. doi: 10.1016/j.neuron.2015.02.010.
8
Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators.
Bioorg Med Chem Lett. 2015 Apr 1;25(7):1621-6. doi: 10.1016/j.bmcl.2015.01.051. Epub 2015 Feb 10.
9
The dynamic conformational landscape of gamma-secretase.
J Cell Sci. 2015 Feb 1;128(3):589-98. doi: 10.1242/jcs.164384.
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Lessons from a failed γ-secretase Alzheimer trial.
Cell. 2014 Nov 6;159(4):721-6. doi: 10.1016/j.cell.2014.10.016.

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