Wang Dong, Chen Fanglian, Han Zhaoli, Yin Zhenyu, Ge Xintong, Lei Ping
Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China.
Tianjin Geriatrics Institute, Tianjin, China.
Front Cell Neurosci. 2021 Jul 19;15:695479. doi: 10.3389/fncel.2021.695479. eCollection 2021.
Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The production and deposition of Aβ are important factors affecting AD progression and prognosis. The deposition of neurotoxic Aβ contributes to damage of the blood-brain barrier. However, the BBB is also crucial in maintaining the normal metabolism of Aβ, and dysfunction of the BBB aggravates Aβ deposition. This review characterizes Aβ deposition and BBB damage in AD, summarizes their interactions, and details their respective mechanisms.
淀粉样蛋白-β（Aβ）是阿尔茨海默病（AD）中主要的病理性蛋白。Aβ的产生和沉积是影响AD进展和预后的重要因素。具有神经毒性的Aβ的沉积会导致血脑屏障受损。然而，血脑屏障在维持Aβ的正常代谢方面也至关重要，血脑屏障功能障碍会加剧Aβ的沉积。本文综述了AD中Aβ沉积和血脑屏障损伤的特征，总结了它们之间的相互作用，并详细阐述了它们各自的机制。
