Fujie Tomoya, Hara Takato, Kaji Toshiyuki
Faculty of Pharmaceutical Sciences, Toho University.
J Toxicol Sci. 2016;41(Special):SP81-SP88. doi: 10.2131/jts.41.SP81.
Bio-organometallics is a research strategy of biology that uses organic-inorganic hybrid molecules. The molecules are expected to exhibit useful bioactivities based on the unique structure formed by interaction between the organic structure and intramolecular metal(s). However, studies on both biology and toxicology of organic-inorganic hybrid molecules have been incompletely performed. There can be two types of toxicological studies of bio-organometallics; one is evaluation of organic-inorganic hybrid molecules and the other is analysis of biological systems from the viewpoint of toxicology using organic-inorganic hybrid molecules. Our recent studies indicate that cytotoxicity of hybrid molecules containing a metal that is nontoxic in inorganic forms can be more toxic than that of hybrid molecules containing a metal that is toxic in inorganic forms when the structure of the ligand is the same. Additionally, it was revealed that organic-inorganic hybrid molecules are useful for analysis of biological systems important for understanding the toxicity of chemical compounds including heavy metals.
生物有机金属化学是一种利用有机-无机杂化分子的生物学研究策略。基于有机结构与分子内金属之间相互作用形成的独特结构，这些分子有望展现出有用的生物活性。然而，关于有机-无机杂化分子的生物学和毒理学研究都尚未全面开展。生物有机金属化学的毒理学研究可能有两种类型；一种是对有机-无机杂化分子的评估，另一种是从毒理学角度利用有机-无机杂化分子对生物系统进行分析。我们最近的研究表明，当配体结构相同时，含有无机形式无毒金属的杂化分子的细胞毒性可能比含有无机形式有毒金属的杂化分子的细胞毒性更大。此外，研究还发现，有机-无机杂化分子有助于分析对于理解包括重金属在内的化合物毒性至关重要的生物系统。
