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肠型腺癌：分类、免疫表型、分子特征及鉴别诊断

Intestinal-Type Adenocarcinoma: Classification, Immunophenotype, Molecular Features and Differential Diagnosis.

作者信息

Leivo Ilmo

机构信息

Department of Pathology and Forensic Medicine, University of Turku, Turku, Finland.

出版信息

Head Neck Pathol. 2017 Sep;11(3):295-300. doi: 10.1007/s12105-017-0800-7. Epub 2017 Mar 20.

DOI:10.1007/s12105-017-0800-7
PMID:28321774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5550401/
Abstract

Intestinal-type adenocarcinoma is the second most frequent sinonasal adenocarcinoma. High incidence of these tumors is seen among workers with occupational wood dust exposure, particularly of hardwood dusts. Intestinal-type adenocarcinoma has striking histomorphologic and immunophenotypic similarities with colorectal adenocarcinomas, but on the level of molecular pathologic mechanisms these tumors have their own specific features different from gastrointestinal tumors. This article provides an update on current histopathologic classification of intestinal-type adenocarcinomas, their immunophenotypic properties, recent advances in molecular pathologic features and differential diagnostic considerations.

摘要

肠型腺癌是第二常见的鼻窦腺癌。这些肿瘤在接触职业性木尘，尤其是硬木尘的工人中发病率较高。肠型腺癌在组织形态学和免疫表型上与结直肠癌有显著相似之处，但在分子病理机制层面，这些肿瘤有其自身不同于胃肠道肿瘤的特定特征。本文提供了肠型腺癌当前组织病理学分类、免疫表型特性、分子病理特征的最新进展以及鉴别诊断考量的最新情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/7710d920eedb/12105_2017_800_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/69528b3e8525/12105_2017_800_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/70271c4c9bcc/12105_2017_800_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/d3842e2cefe3/12105_2017_800_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/c28508f9d5ca/12105_2017_800_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/7710d920eedb/12105_2017_800_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/69528b3e8525/12105_2017_800_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/70271c4c9bcc/12105_2017_800_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/d3842e2cefe3/12105_2017_800_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/c28508f9d5ca/12105_2017_800_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/614f/5550401/7710d920eedb/12105_2017_800_Fig5_HTML.jpg

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Study of MET protein levels and MET gene copy number in 72 sinonasal intestinal-type adenocarcinomas.
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Int J Mol Sci. 2024 Apr 24;25(9):4630. doi: 10.3390/ijms25094630.
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