端粒长度与糖尿病之间的关联：一项荟萃分析。
Association between telomere length and diabetes mellitus: A meta-analysis.
作者信息
Wang Jianfei, Dong Xu, Cao Li, Sun Yangyang, Qiu Yu, Zhang Yi, Cao Ruoqiong, Covasa Mihai, Zhong Li
机构信息
1 Laboratory of Biology Chip, College of Life Sciences, Hebei University, Baoding, China.
2 Western University of Health Sciences, College of Osteopathic Medicine, Pomona, CA, USA.
出版信息
J Int Med Res. 2016 Dec;44(6):1156-1173. doi: 10.1177/0300060516667132. Epub 2016 Nov 11.
Objective We investigated the relationship between diabetes and telomere length by meta-analysis. Methods We searched five popular databases for articles published between 1990 and 2015 using "diabetes" and "telomere" as search terms. Data were processed with RevMan5, and random- or fixed-effects meta-analysis was applied. The effects of geographical region, diabetes type, body mass index (BMI), age and sex were examined. Funnel plots were applied to evaluate publication bias. Results Seventeen articles were obtained from 571 references. We identified a significant association between telomere length and diabetes mellitus (standardized mean difference [SMD]: -3.41; 95% confidence interval [CI]: -4.01, -2.80; heterogeneity, I= 99%) by comparing 5575 patients with diabetes and 6349 healthy individuals. The pooled SMD by geographic region indicated a significant association between shortened telomere length and diabetes mellitus (SMD: -3.41; 95% CI: -4.01, -2.80; heterogeneity, I= 99%). In addition, telomere length was significantly associated with age (SMD: -3.41; 95% CI: -4.01, -2.80), diabetes type (SMD: -3.41; 95% CI: -4.01, -2.80), BMI (SMD: -1.61; 95% CI: -1.98, -1.23) and sex (SMD: -4.94; 95% CI: -9.47, -0.40). Conclusions The study demonstrated a close relationship between diabetes mellitus and telomere length, which was influenced by region, age, diabetes type, BMI and sex.
目的 通过荟萃分析研究糖尿病与端粒长度之间的关系。方法 我们以“糖尿病”和“端粒”作为检索词，在五个常用数据库中搜索1990年至2015年发表的文章。使用RevMan5对数据进行处理，并应用随机或固定效应荟萃分析。研究了地理区域、糖尿病类型、体重指数（BMI）、年龄和性别的影响。采用漏斗图评估发表偏倚。结果 从571篇参考文献中获得17篇文章。通过比较5575例糖尿病患者和6349例健康个体，我们发现端粒长度与糖尿病之间存在显著关联（标准化平均差[SMD]：-3.41；95%置信区间[CI]：-4.01，-2.80；异质性，I=99%）。按地理区域汇总的SMD表明，端粒长度缩短与糖尿病之间存在显著关联（SMD：-3.41；95%CI：-4.01，-2.80；异质性，I=99%）。此外，端粒长度与年龄（SMD：-3.41；95%CI：-4.01，-2.80）、糖尿病类型（SMD：-3.41；95%CI：-4.01，-2.80）、BMI（SMD：-1.61；95%CI：-1.98，-1.23）和性别（SMD：-4.94；95%CI：-9.47，-0.40）显著相关。结论 该研究表明糖尿病与端粒长度之间存在密切关系，且受区域、年龄、糖尿病类型、BMI和性别的影响。
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