Crowley Marci G, Liska M Grant, Lippert Trenton, Corey Sydney, Borlongan Cesar V
Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, United States.
CNS Neurol Disord Drug Targets. 2017;16(4):414-424. doi: 10.2174/1871527316666170320150659.
The opioid system has been elucidated as a potential target for therapy in a variety of neurological disorders including stroke. Delta opioid receptors have been revealed to pose an especially compelling biological function for new neuroprotective therapies. Two distinct therapeutic mechanisms have been characterized for delta opioid receptors, namely, these receptors aid in maintaining ionic homeostasis and initiate endogenous neuroprotective pathways. Specific agonists of delta opioid receptors, such as (D-Ala2, D-Leu5) enkephalin (DADLE), have displayed the ability to promote neuronal survival and mitigate apoptotic pathways. These findings have led to a significant amount of research on this molecule's potential as a neurotherapeutic. At the forefront of these efforts has been investigation into DADLE's ability to protect neurons and glial cells following ischemia. Additionally, current research is attempting to reveal the dynamic neuroprotective mechanisms that mediate DADLE's therapeutic benefits. This review article discusses the scientific evidence supporting the use of delta opioid family of receptors and ligands as a promising target for therapeutic intervention in neurological disorders, with emphasis on stroke.
阿片类系统已被阐明是包括中风在内的多种神经系统疾病治疗的潜在靶点。δ阿片受体已被发现对新型神经保护疗法具有特别引人注目的生物学功能。δ阿片受体具有两种不同的治疗机制，即这些受体有助于维持离子稳态并启动内源性神经保护途径。δ阿片受体的特异性激动剂，如（D-丙氨酸2，D-亮氨酸5）脑啡肽（DADLE），已显示出促进神经元存活和减轻凋亡途径的能力。这些发现引发了大量关于该分子作为神经治疗剂潜力的研究。这些努力的前沿是研究DADLE在缺血后保护神经元和神经胶质细胞的能力。此外，目前的研究试图揭示介导DADLE治疗益处的动态神经保护机制。这篇综述文章讨论了支持将δ阿片受体家族和配体用作神经系统疾病，尤其是中风治疗干预有前景靶点的科学证据。
